A Stochastic Model of Cell Differentiation B. Laforge LPNHE Paris, Université Paris VI

This presentation explores a stochastic model of cell differentiation and tissue organization based on gene expression equilibrium. It delves into the autonomous stabilization of stochastic gene expression and interdependencies for cell proliferation. With a focus on Darwinian and cell identification models, the study uses simulation to analyze intrinsic properties, cellular interactions, and molecular processes. Results showcase bi-layer structure formation, molecular gradients, and embryo mortality implications. The impacts of disruptions to equilibrium, cell death, and stochasticity on organism development are also discussed.

• stochastic model
• cell differentiation
• gene expression
• tissue organization
• embryogenesis
• cancer
• simulation
• biological processes

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