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Target agent: VX

Explore how peptides and metals can distinguish between nerve agents like VX and pesticides, aiding in identification and prevention. Investigate the selectivity and recognition abilities of peptide and metal receptors for different types of compounds.

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Target agent: VX

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  1. O CH CH CH CH CH CH CH CH CH CH CH CH CH O 3 3 3 3 3 3 3 3 3 3 3 3 3 P N S CH 3 H C 3 CH 3 VX O H C H C H C H C 3 3 3 3 O P F sarin CO Et 2 NO 2 CO Et 2 parathion Target agent: VX O N O acetylcholine Other chemical agents: O O O N P P F CN soman tabun Pesticides: S S O O P P O O O S malathion

  2. O CH CH CH CH CH O 3 3 3 3 3 P N S CH 3 H C 3 CH 3 VX H C 3 Target agent: VX O N O acetylcholine Acetylcholinesterase

  3. CH CH CH CH CH CH CH CH 3 3 3 3 3 3 3 3 O H C H C H C 3 3 3 O P F sarin CO Et 2 NO 2 CO Et 2 parathion Organophosphorus Compounds Other chemical agents: O O O N P P F CN soman tabun Pesticides: S S O O P P O O O S malathion

  4. NH N N H 2 2 H NH NH NH 2 NH N 2 2 2 N H H Peptides that recognize VX Dr. Cyndi Wells, Dr. Ben Warner, Los Alamos Natl. Lab. NH2-Ser-GG-Arg-GG-His-GG-His-Phe NH2-Arg-GG-Ser-GG-His-GG-Ser-Phe NH2-Trp-GG-His-GG-His-GG-Trp-Phe NH2-Arg-GG-Tyr-GG-Arg-GG-Ser-Phe NH2-Tyr-GG-Trp-GG-Tyr-GG-Trp-Phe NH2-His-GG-His-GG-His-GG-Arg-Phe O O O O NH O N HO OH HO HO HO HO OH Ser Arg His Tyr Trp

  5. Peptide: hydrophobic/hydrophilic, shape, size Metal: functional group discrimination H C 3 methylphosphonic acid thiophosphates from nerve agents from pesticides H O H C 2 H C 3 3 m ethylphosphonic e thanol m ercaptoamine acid Selectivity and Recognition:Peptide/metal receptors O O S OH OH OH P P P HO OH HO OH OH phosphates from soil differentiate by metal differentiate by peptide Degradation Products: O O HS N O OH P + + P + HO OH S N VX

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