1 / 36

es1261.8m/ed25.gif

http://es1261.8m.com/ed25.gif. Bridges to Structure. Peter Woodruff Stacey Kiser Joyce Cadwallader. …. Traditional “Systems Biology”. Organ Systems. Dissection Form Function. …. Building Investigations at Different Levels of Structure.

aderes
Download Presentation

es1261.8m/ed25.gif

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. http://es1261.8m.com/ed25.gif

  2. Bridges to Structure Peter Woodruff Stacey Kiser Joyce Cadwallader

  3. … Traditional “Systems Biology” Organ Systems

  4. DissectionFormFunction

  5. …

  6. Building Investigations at Different Levels of Structure http://www.nsf.gov/od/lpa/forum/colwell/rc03norwaycsis/sld011.htm

  7. molecules Size Macro Cells Tissues Organs

  8. molecules Size Macro Time Cells Tissues Organs Phylogeny ontogeny

  9. Multidimensional Systems Space http://tetraspace.alkaline.org/

  10. Brian White’s Course Web Site

  11. Phylogenetic Tree Instructions

  12. Choosing Organisms

  13. Results

  14. Protein Structure Investigation • The students will investigate protein structure (Problem Posing) by use of the Biology Workbench and NCBI. • They will get information from the NCBI web site about a protein they think might be representative of a particular organ system. • They will then gather the materials from that site to dissect the structure of their protein including a visual representation (Problem Solving).

  15. Protein Structure Comparison • Either using the NCBI or Workbench sequences,they will use Workbench to do additional trees of representative proteins of a particular organ system • They will present their findings on the proteins in class.

  16. Get NCBI Protein File

  17. Get a List of Similar Molecules

  18. Get Structure

  19. Workbench.sdsc.edu

  20. Work in Progress • Adding activities from Comparative Genome site would be helpful, but time allowed only a start. • Although we have provided some ascension numbers for proteins, remember only genomic sequences work in this database (Find them at NCBL.).

  21. Workbench (Organisms Used)

  22. Workbench Alignment Data

  23. Respiratory: CFTR http://www.people.virginia.edu/~rjh9u/gif/cftr.gif http://www.brunel.ac.uk/depts/bl/project/biocomp/sequence/seqanal_guide/pds/cftr.jpg

  24. Respiratory: Surfactant Protein D Human surfactant protein D (pdb entry:1b08) http://ashtoret.tau.ac.il/~sharon/hspd.jpg

  25. Reproductive: Estrogen receptor1ERE http://www.bch.msu.edu/~kuhn/projects/screening/er.jpg

  26. Immune System:Immunoglobulin, Variable Region& Interleukin-1 Beta Cn3D of cd00099.3, IGv Cn#D of2MIB

  27. Skeletal: Collagen Cn3D of 1CGD

  28. Muscular: Tropomyosin Cn3D of 1IC2 http://202.20.99.18/~jjkim/Lecture/Animalphy/Ap10muscle/actin-ca.gif

  29. Workbench Unrooted Tree

  30. www.dcode.org

  31. Data from search for estrogen receptor

  32. Conservation Information for Estrogen Receptor

  33. Bringing Dissection Up to Date http://www.activehistory.co.uk/2nds/TudorProject/tudor_medicine_and_health.htm http://mason.gmu.edu/~dgomez2/

More Related