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Giorgio F. Pacelli MD, Vito Belloli MD, UOC oculistica, Ospedale di Arona (No).

Rapid unusual reasorbtion of drusenoid subfoveal lesions in AMD and pseudovitelliform maculopathy documented with SD-OCT and autofluorescence. Giorgio F. Pacelli MD, Vito Belloli MD, UOC oculistica, Ospedale di Arona (No).

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Giorgio F. Pacelli MD, Vito Belloli MD, UOC oculistica, Ospedale di Arona (No).

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  1. Rapid unusual reasorbtion of drusenoid subfoveal lesions in AMD and pseudovitelliform maculopathydocumented with SD-OCT and autofluorescence. Giorgio F. Pacelli MD, Vito Belloli MD, UOC oculistica, Ospedale di Arona (No).

  2. Case Report 1: BO 72 years old female February 2009:daily intake of an AREDS2 formulation containing microalgale DHA e tocotrienols Visus 0,9 0,1 logmar Visus 10/10 0,0 logmar 8 months’ follow-up 20 months’ follow-up

  3. 8 months’ follow-up Autofluorescence evolution. Baseline 1 & ½ year follow-up

  4. BO: Fellow eye evolution. ETDRS BCVA 0.0 logm 8 months’ evolution ETDRS BCVA 0.0 logm 20 months’evolution

  5. 8 months’ follow-up Autofluorescence evolution Baseline 20 months’ evolution

  6. Case report 2 (MC): 75 years old famaleareds 4 category AMD left eyedaily intake of an AREDS2 formulation containing microalgale DHA e tocotrienols BCVA: 0.8 dec 0.16 logm 18 Months later 8 months later BCVA 1.0 dec 0.0 logm

  7. 8 months later baseline AF evolution: 18 months later

  8. (MC)_ SD-OCT Cirrus Zeiss Follow up ( RPElevel scan slice )

  9. Case report 3: (BD): 80 years old male may 2009: daily intake of an AREDS2 formulation containing microalgale DHA e tocotrienols BCVA 0.6 dec; 0.24 logmar +1 .75 sf Case report 3(BD): 04-10 ( 12 months’ follow up) BCVA 0.9 dec; 0.04 logmar +0.75 sf

  10. BD: Right eye of the same patients: BCVA 1.0 BCVA 1.0 12 months later

  11. Case report 4 RA: AMD with RPE pattern shape abnormalities and metamorphopsia complaint in the latest 2 months: (AREDS 4 category: controlateral eyes evoluted AMD):

  12. BCVA 0.5 dec; 0,3 logmar Case report 4: areds 2 formulation prescription 8 months later: 0.9 dec: 0.04 logm 3 montths later: BCVA 0.8 dec)

  13. Case report 6 (BI): baseline oct 08: BCVA 0.9 dec; 0.06 logmar extrafoveal CNV treated directly with argon laser in a patients supplemented with AREDS1 formulation 3 mos later: BCVA 0.9 dec ( 0.1 log); Increment in soft drusen confluence; no more evidence of CNV

  14. 05-10 BCVA 0.9 0.1 logm 20 months later after a daily intake of an AREDS2 formulation containing ω3-microalgale & tocotrienols 08-2010 BCVA 0.9 0.04 logm

  15. Case report 7: Pseudovitelliform macular lesion with a subfoveal lipofusinic accumulation (BS). Daily intake of AREDS2 (tocotrienols e microalgale ω3 ): BCVA 0.8 dec ( 0.1 logmar) 6 months later: BCVA 0.9 ( 0,08 logmar)

  16. BS: 15 months later: further reduction of lipofuscine.

  17. Case report 7: Left eye: PV maculopathy & foveal PRC misalignement BCVA 0.8 (0.1 logmar) 6 months later: BCVA 0.9 ( 0.02 logmar)

  18. 15 months later: regularization of PRC disalignament

  19. PV maculopathy treated with an areds1 formulation: BCVA 0.8 ( 0.1 logmar) ILM- EPR Line

  20. 1 year follow up (ω3 free formulation): BCVA 0.1 dec 1.0 logmar (!!!!) Linea ILM EPR post Linea ILM- EPR pre

  21. Take home message: • The evidence of SD OCT and AF evolution of these drusenoid lesions suggest the utility of AREDS-2 formulation in preventing AMD evolution, waiting for confirmatory results coming out from ongoing AREDS2 studies. Thank you for your attention

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