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Fundamentals of Powder Compression

Fundamentals of Powder Compression. attractive forces exist between particles van der Waal’s, H-bonding, electrostatic consider a number of granules in a die to which a force is applied. Compression. consider the force transmitted through the powder bed

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Fundamentals of Powder Compression

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  1. Fundamentals of Powder Compression • attractive forces exist between particles • van der Waal’s, H-bonding, electrostatic consider a number of granules in a die to which a force is applied CHEE 440

  2. Compression • consider the force transmitted through the powder bed • descending upper punch, stationary lower punch CHEE 440

  3. Force-Volume relationships • at the end of the compression stage the initial porosity has been decreased • need some porosity for disintegration therefore need relation between force applied (FA) and porosity (e) CHEE 440

  4. Heckel Plots CHEE 440

  5. Force-displacement CHEE 440

  6. Role of Moisture CHEE 440

  7. Influence on Bioavailability • compression force affects disintegration time of tablet CHEE 440

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