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General Shape of a Smooth Muscle Cell

General Shape of a Smooth Muscle Cell. Smooth Muscle Motor Units?. Contraction Patterns in Smooth Muscles. Phasic (quick, SkMus-like) and tonic contractions. EC Coupling in Smooth Muscle. Thin and Thick Filament Arrangements in Smooth Muscle. Caldesmon. Caldesmon In Relaxed Fibers.

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General Shape of a Smooth Muscle Cell

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  1. General Shape of a Smooth Muscle Cell

  2. Smooth Muscle Motor Units?

  3. Contraction Patterns in Smooth Muscles Phasic (quick, SkMus-like) and tonic contractions

  4. EC Coupling in Smooth Muscle

  5. Thin and Thick Filament Arrangements in Smooth Muscle

  6. Caldesmon

  7. Caldesmon In Relaxed Fibers

  8. Regulation of Smooth Muscle Contraction Thick Filament Regulation (on myosin light chain): -- Modulation by MLCK/MLCP -- Other Mechanisms Thin Filament Regulation (?): -- Does caldesmon have a regulatory role? -- Other mechanisms

  9. Calcium and the Control of MLCK Leading to Control of the Myosin Light Chain

  10. Contracted SM Mus

  11. There’s always a reverse process: MLCP phosphatase is inhibited by a Ca++ dependent pathway (but in any case, its maximum activity is lower than MLCK)

  12. SM Contraction and Relaxation: Ca++ and the Regulation of Phosphorylation of the Myosin Light Chain

  13. Regulation via the PKC Pathway

  14. Latch Mechanism?

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