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Welcome to the Molecular Medicine course!. Registration. General information Over-arching goals Roll call Course contents Information about KS library Coffee Course evaluation HT 2009 Study design (research application) Seminar assignment Final examination Study visit
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Registration • General information • Over-arching goals • Roll call • Course contents • Information about KS library • Coffee • Course evaluation HT 2009 • Study design (research application) • Seminar assignment • Final examination • Study visit • Molecular Medicine - from bed to bench
Course leader: Rachel Fisher 08-517 732 45 rachel.fisher@ki.se Deputy course leader: Ewa Ehrenborg 08-517 761 91 ewa.ehrenborg@ki.se Teaching assistant: Louisa Cheung 08-517 732 21 louisa.cheung@ki.se Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, L8:02 Course secretary: Sofia Asp Department of Medicine, Unit for Internal Medicine, Karolinska University Hospital, A3:02 08-517 716 33 sofia.asp@ki.se Office hours daily 9.00am - 3.00pm
Over-arching goals • To integrate previously gained knowledge • To stimulate team work • To analyse, evaluate and interpret raw data • To design a study and write a research application • To provide “real life” experience
Course set up • Lectures usually 9am – 3pm (check venue!) • Labs/demonstrations/seminars usually in groups • Time scheduled for group work • Seminar assignment • Presentation of group work (research application) near end of course • Study visit to AstraZeneca • Revision time (last timetabled activity 17th Dec) • Final written examination: 12th January
Course contents (15 hp/ECTS) • Specific areas • Circulation, Ischemia, Metabolic Syndrome, Diabetes 4 w • Gastroenterology 1 w • Endocrinology 1 w • Respiration, asthma & allergy 1 w • Pathology 1 w • Clin immunology/Clin chemistry 1 w • 9 w • Assignments etc. • Molecular biology lab (incl. inter-professional experience) • Seminars • Research application • Study visit • Seminar assignment • Revision Integrated
Course literature • Text books from previous courses: physiology, pharmacology, biochemistry, molecular genetics, immunology • Articles and links on the web page • Lecture summary points (from lecturers)
Seminar assignment Lab “Methods in Molecular Biology” Lectures, demos, labs, exam Pathology seminars Research plan
Labs and Demonstrations • Lab: “Methods in Molecular Biology – Theory and Practice” • (3/11, 16-18/11, 23-25/11, 30/11-2/12, 7/12 (statistics), 10/12) • Angiography demonstration (15/11) • Lung/allergy demonstration (9/11) • Blood grouping lab (8-9/12)
Labs • You must bring your own lab coats! • Some labs and demonstrations will be performed in active research labs- show consideration for those who work there
Pathology seminars • Pathology integrated into the course • 3 seminars: Atherosclerosis (17-19/11) Endocrinology (24-26/11) Gastrointestinal (1-3/12) • At HuddingeTeacher-led session (10 - 11am)Self-study (11am – 12noon, 1 - 2pm)Review with teacher (2 - 3pm)
Course evaluation HT 2009 Good • Research application • Lab “Methods in Molecular Biology” • AstraZeneca, Göteborg • Course leaders/administration Mixed • Clinical emphasis • Pathology seminars • Written assignment • Lecturers Bad • Lack of a course text book • Some repetition within lectures • Too many lectures
New for HT 2010 • Many lectures removed • Seminar assignment (replace written assignment) • New Pathology seminar (GI) • Modified data analysis of Lab “Methods in Molecular Biology” • Spread work load more evenly over course • Lighter schedule at end of course to allow time for revision
Evaluation of the course • We rely on your feedback to improve the course • Please give constructive feedback • Evaluation forms (online) • Cinema ticket voucher if all evaluation forms completed + submitted! • Course councils • with representatives 29/11 • with whole class 16/12
Forms of feedback reviewing progress with students Research application feedback on assignments & exam editing and redrafting Methods in mol biol Pre-submission guidance and feedback Research application feedforward assignments Research application Informing about feedback whole-class feedback Methods in mol biol
Course language • All literature in English • Lectures in English • All assignments may be written in either English or Swedish
Research application • Group assignment • Choose a specific issue to focus on • Design a research project • Write a research application • Present the project orally • Answer questions • Team work • Realistic exercise
Research application:groups and topics • Groups 1-6 each split in 2 • 12 ”subgroups” of 3-4 people • Each subgroup allocated a broad topic • Detailed project chosen by the subgroup • Discussions with and feed back from topic ”mentor”
Inflammation in cardiovascular disease Transcription factor regulation in inflammation Aneurysm Energy metabolism (endocrinology) Allergy Diabetes and co-morbidities Metabolism and cardiovascular disease Mesenchymal stem cells and bone formation Asthma Thrombosis and haemostasis Liver Proteoglycans and cardiovascular disease Research application – broad topics 2 topics/group, 3-4 people/research application
Seminar assignment • Handed out at course start • Group work / individual assessment • Research based aspects, requires independent work • Grading = pass / fail • Replaces “Written Assignment”
Examination • Final examination: Wednesday 12 January Grades A-F • Questions testing knowledge + understanding
Grading of the examination • F, Fx, E, D, C, B, A • Goal-based assessment • Evaluating the level of knowledge obtained NOT the amount of knowledge • F, Fx = fail • E = basic pass: identify, describe, list • C, D = pass with merit: compare, explain connections, analyse, apply • B, A = pass with distinction: theorise, hypothesise, reflect
One relevant aspect Several relevant independent aspects Integrated into a structure Generalized to new domain Extended abstract B, A Relational C, D Prestructural F Multistructural E Unistructural Fx
To pass the course … • The student must obtain a grade of at least E for the written examination (5 hp) • The student must also pass • the seminar assignment (3 hp) • the research application (3 hp) • all labs, demonstrations, seminars (4 hp)
Replacement assignments • When compulsory parts of the course are missed, there are replacement exercises • If written, these must be handed in by the last day of the course (14 January 2011) • Next opportunity for submission = next course (HT2011)
AstraZeneca, Göteborg • Coach journey Thursday 13/1, 10.00am • Eat dinner together • Study visit Friday 14/1, 8.30am – 3.30pm • Information + presentations • Guided tour of labs • Return journey, depart around 3.30pm • Contribution of 250kr/person
Information about Masters Programme • 6th December, 3pm • Medicine Lecture Theatre (A6:04) • Dan Grandér
Molecular Medicine:from bed to bench • Important clinical contact • Translational research • Cross-disciplinary • “From bench to bed and back again”