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Using Drug Ontology to Bridge Clinical Trial Eligibility and Patient Record

Using Drug Ontology to Bridge Clinical Trial Eligibility and Patient Record. Helen Chen July 1, 2008. Drug Class Information in CT #8. monotherapy with metformin , insulin secretagogue , or alpha-glucosidase inhibitors and a low dose combination of all Long term insulin therapy

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Using Drug Ontology to Bridge Clinical Trial Eligibility and Patient Record

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  1. Using Drug Ontology to Bridge Clinical Trial Eligibility and Patient Record Helen Chen July 1, 2008

  2. Drug Class Information in CT #8 • monotherapy with metformin, insulin secretagogue, or alpha-glucosidase inhibitors and a low dose combination of all • Long term insulin therapy • Therapy with rosiglitazone (Avandia) or pioglitazone (Actos), or extendin-4 (Byetta), alone or in combination • corticosteroids • weightloss drugs e.g., Xenical (orlistat), Meridia (sibutramine), Acutrim (phenylpropanol-amine), or similar medications • nonsteroidal anti-inflammatory drugs • Use of warfarin (Coumadin), clopidogrel (Plavix) or other anticoagulants • Use of probenecid (Benemid, Probalan), sulfinpyrazone (Anturane) or other uricosuric agents

  3. Prescription Information in Patient Database NDC Code • "132139","131933","98630 ","GlipiZIDE-Metformin HCl 2.5-250 MG Tablet","54868079500 ",98630,"2.5-250 ","TABS","","MG "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl 2.5-250 MG Tablet" • "132152","131946","98629 ","GlipiZIDE-Metformin HCl 2.5-500 MG Tablet","54868518802 ",98629,"2.5-500 ","TABS","","MG "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl 2.5-500 MG Tablet" • "132407","132201","98628 ","GlipiZIDE-Metformin HCl 5-500 MG Tablet","54868546702 ",98628,"5-500 ","TABS","","MG "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl 5-500 MG Tablet" • "132642","132436","C98630 ","GlipiZIDE-Metformin HCl TABS","54868079500 ",98630,"","TABS",""," "," ","15","GlipiZIDE-Metformin HCl ","","GlipiZIDE-Metformin HCl TABS"

  4. Drug Ontology By Samson et al • project seeks to discover new therapeutic uses and adverse effects of drugs by finding diseases that have gene expression profiles similar to those of the known indications and adverse effects of drugs

  5. Drug Ontology By Samson et al – quoted from drug ontology documentation

  6. Mapping Needed Between CT and Patient Record Drug Ontology CT MechanismOfAction C1299007 metformin, C0050393 C0066535 insulin secretagogue GeneralDrugType nonsteroidal anti-inflammatory drugBank: DB00331 RxNORM: 6809 alpha-glucosidase inhibitors C0025598 anticoagulants uricosuricagents NDC:54868079500:GlipiZIDE-Metformin HCl 2.5-250 MG Tablet NDC: 54868518802: GlipiZIDE-Metformin HCl 5-500 MG Tablet NDC:54868079500:GlipiZIDE-Metformin HCl TABS

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