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菌心说 --- 一场静悄悄的革命

菌心说 --- 一场静悄悄的革命. 思想要创新 科研要创新 医疗要创新 知识要创新. 北美医学教育基金会. 创新是一个民族进步的灵魂，是一个国家兴旺发达的不竭动力. 张成岗提出菌心说. 【 菌心说 】 意味着人类对于自己、社会以及自然的认识前进了一大步. 军事医学科学院放射与辐射医学研究所电磁与激光生物学研究室主任，研究员，博士生导师，蛋白质组学国家重点实验室副主任。. 目录. 我对菌心说的理解 肠道菌群与健康和疾病概述 肠 - 脑轴 肠 - 肝轴 肠道菌群与代谢性疾病：肥胖、糖尿病 肠道菌群与肠病 肠道菌群与免疫 肠道菌群与其它疾病

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菌心说 --- 一场静悄悄的革命

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  1. 菌心说---一场静悄悄的革命 思想要创新 科研要创新 医疗要创新 知识要创新 北美医学教育基金会 创新是一个民族进步的灵魂，是一个国家兴旺发达的不竭动力

  2. 张成岗提出菌心说 【菌心说】意味着人类对于自己、社会以及自然的认识前进了一大步 军事医学科学院放射与辐射医学研究所电磁与激光生物学研究室主任，研究员，博士生导师，蛋白质组学国家重点实验室副主任。

  3. 目录 • 我对菌心说的理解 • 肠道菌群与健康和疾病概述 • 肠-脑轴 • 肠-肝轴 • 肠道菌群与代谢性疾病：肥胖、糖尿病 • 肠道菌群与肠病 • 肠道菌群与免疫 • 肠道菌群与其它疾病 • 革命带来的挑战和机遇 菌心说是一个概括

  4. 我对菌心说的理解 • 肠道菌群是人体健康和疾病的核心。 • 肠道菌群是人生存的一个中心器官。 • 肠道菌群和“心”的关系： • 脑肠轴的概念 • 肠道菌群和心血管疾病

  5. 主要创始人 • 学历: • Tufts大学博士后 • Boston大学博士 • 美国国际教育中心医学博士认证 • 北京体育大学运动医学硕士 • 首都医科大学学士 • 工作经历 • 美国USDA HNRCA副研究员 • Boston 大学教授助理 • Quincy 学院讲师 • 哈佛大学研究助理 美国广州、沈阳总领事商务副领事感谢北美医学基金会和北美医学教育基金会对中美医学交流的支持和贡献，专程到我们的展位表示谢意。 • 北美医学教育基金会主要创始人

  6. Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.

  7. Through the ongoing National Institutes of Health Roadmap ‘Human Microbiome Project’ and similar projects in other parts of the world, a large coordinated effort is currently underway to study how microbiota can impact human health. Translating findings from these studies into effective interventions that can improve health, possibly personalized based on an individuals existing microbiota, will be the task for the next decade(s).

  8. 悄悄发生的革命 INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;

  9. 一篇值得关注的综述 Nature reviews. Microbiology 最新的影响因子为22.490 (2013)

  10. 人菌共生 Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.

  11. 人肠道菌群种类和数量 EAMONN M. M. QUIGLEY and RODRIGO QUERA, Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics. GASTROENTEROLOGY 2006;130:S78–S90

  12. 好细菌和坏细菌

  13. 菌群是健康的核心 Nathalie M. Delzenne, et al., Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639–646 (2011).

  14. 肠道菌群对人生理的影响

  15. 肠道菌群-代谢产物-功能 Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.

  16. 影响肠道菌群的因素 Nathalie M. Delzenne & Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.

  17. 影响肠道菌群的因素

  18. 肠道菌群紊乱引发的疾病

  19. 肠-脑轴/脑-肠轴

  20. Germ Free (GF) Mice Display Increased Motor Activity and Reduced Anxiety-Like Behavior. • results suggest that the microbial colonization process initiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.

  21. 肠-脑轴的概念 Augusto J. Montiel-Castro, et al., The microbiota–gut–rainaxis: neurobehavioral correlates, healthand sociality. Front in Integ Neuro. Oct 2013 | Vol7 | Article 70 | 1-16.

  22. 脑-肠轴/肠-脑轴：迷走神经 Sue Grenham,et al., Brain–gut–microbe communication in health and disease. Frontiers in Physio. Gastroint Sci Dec 2011 Vol 2 p 1-15.

  23. 肠脑轴/脑肠轴 Q. AZIZ, et al., Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil (2013) 25, 4–15.

  24. 菌群影响神经功能 Eamonn M.M. Quigley. Do patients with functional gastrointestinal disorders have an altered gut flora? Ther Adv Gastroenterol (2009) 2(Suppl 1) S23–S30.

  25. 菌群紊乱致焦虑和抑郁 Jane A. Foster and Karen-Anne McVey Neufeld, Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, May 2013, Vol. 36, No. 5, P 305-312

  26. 精神活动影响肠道菌群 exposure to psychological stress results in a significant reduction in the production of mucin and a decreased presence of acidic mucopolysaccharides on the mucosal surface. Jason A. Hawrelak & Stephen P. Myers, The Causes of Intestinal Dysbiosis: A Review. Altern Med Rev 2004;9(2):180-197.

  27. 应激/压力引起胃肠疾病 P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.

  28. 脑肠轴紊乱导致溃疡 P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.

  29. 应激导致IBD P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.

  30. 应激导致IBS P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.

  31. 慢性疲劳与肠-脑轴

  32. 肠道菌群和自闭症 • GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD. • Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors. • autism, and likely other behavioral conditions, are potentially diseases involving the gut that ultimately impact the immune, metabolic, and nervous systems, and that microbiome-mediated therapies may be a safe and effective treatment for these neurodevelopmental disorders. • these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders. Elaine Y. Hsiao, et al., Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders. Cell 155, 1451–1463,

  33. 肠-脑轴和自闭症 Caroline G.M. de Theije, et al., Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management. European Journal of Pharmacology 668 (2011) S70–S80

  34. 肠-肝轴 1998年马歇尔提出了“肠-肝轴”的概念 • 对肠道和肝脏功能关系的认识提示新的治疗理念,为肠道和肝脏疾病的治疗探寻新的治疗靶点。 Eamonn M. M. Quigley, Gut Bacteria in Health and Disease. Gastro & Hepat Vol 9, 9, 2013, P 560-569.

  35. 肠-肝轴之间的互动 肠道菌群失调，大量G-杆菌繁殖,LPS产生显著增多肠粘膜屏障功能受损 肝功能异常KCs代谢和清除LPS降低，导致肠道功能异常 致病菌和LPS大量移位，经门静脉入肝，损害肝功能。 Gakuhei Son, et al., Contribution of Gut Bacteria to Liver Pathobiology. Gastroe Res and Prac, Vol 2010, Article ID 453563, 13 pages.

  36. 肠肝对话

  37. 肠道菌群致非酒精性脂肪肝 Valentina Tremaroli & Fredrik Bäckhed, Functional interactions between the gut microbiota and host metabolism. NATURE | VOL 489 | 13 SEPTEMBER 2012

  38. 肠道菌群导致脂肪肝 Carmine Finelli and Giovanni Tarantino, NONALCOHOLIC FATTY LIVER DISEASE, DIET AND GUT MICROBIOTA.EXCLI Journal 2014;13:461-490

  39. 肝脏疾病和SIBO

  40. 肠道菌群与代谢性疾病

  41. 肠道菌群增加能量储存 Nathalie M. Delzenne & Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.

  42. 肠道菌群导致能量聚集 Patrice D Cani and Nathalie M Delzenne, Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Current Opinion in Pharmacology 2009, 9:737–743.

  43. 肠道菌群引发多种代谢疾病

  44. 肠道菌群致肥胖-糖尿病机理 Patrice D. Cani,et al., Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes 3:4, 279-288.

  45. 肠道菌群和肥胖

  46. 肠道菌群和肥胖是一个新的热门话题

  47. 肥胖的定义 • 肥胖病一般被定义作为有 BMI 30 以上。 体重将近900磅(约400公斤)的里基(Ricky Naputi)现年39岁，是世界最重的男子之一。因为体型过于笨重而难以移动，他已经在坐落于太平洋关岛的家中躺了五年之久。

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