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Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease

Mouse models of asthma". Allergic inflammation induced by ovalbumin sensitizationmand challengeIntra-tracheal instillation of poly-L-lysine. Hypothesis: Allergic inflammation in mice reproduces important features of asthma and results in airways hyperresponsiveness to methacholine.. treatment gr

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Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease

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    1. Lung Mechanics: Theory and Practice V Lung Mechanics in Mouse Models of Pulmonary Disease Jason H.T. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center University of Vermont College of Medicine

    2. Mouse models of “asthma”

    17. Conclusion?

    20. Conclusion?

    21. Mouse model of parenchymal disease

    25. Conclusion?

    26. Mouse model of acute respiratory distress syndrome

    30. Conclusion?

    31. Summary Airways hyperresponsiveness in mice can be induced by a variety of mechanisms, only some of which have anything to do with abnormalities of airway smooth muscle function Lung diseases produced by a single genetic defect may resemble a combination of classic human pulmonary diseases Lung derecruitment in acute lung injury depends on time as well as inflation pressure and the severity of the injury

    33. QUESTIONS/DISCUSSION?

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