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Undergraduate Laboratory Research by Community College Students: Episode 2

Undergraduate Laboratory Research by Community College Students: Episode 2. Derek Ross, Arlene Flores, Dennis Mitchell (Los Angeles City College) Donald Deardorff (Occidental College). Los Angeles City College About 15,000 students, located in Hollywood,

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Undergraduate Laboratory Research by Community College Students: Episode 2

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  1. Undergraduate Laboratory Research by Community College Students: Episode 2 Derek Ross, Arlene Flores, Dennis Mitchell (Los Angeles City College) Donald Deardorff (Occidental College)

  2. Los Angeles City College About 15,000 students, located in Hollywood, one of nine colleges in the Los Angeles Community College District Occidental College About 1800 students, located in Eagle Rock, a suburb of Los Angeles, a highly selective, four-year, private liberal arts college

  3. First project (Su’03), by Armen Mardiros, Glendale College. Synthesis of compounds for the study of electron transfer between a gold electrode and a protein. The general synthetic strategy is shown below:

  4. Second project (Su ‘04), by Amit Vachher-Gnanathurai, Los Angeles City College. Synthesis of potential glycosidase inhibitors. This project continues.

  5. The general synthetic scheme for Amit:

  6. Derek Ross and Arlene Flores accomplished part of the continuing project at Los Angeles City College Their synthetic goal is shown below:

  7. Value of [approximately 16o

  8. Derek now works on two projects at Occidental College: 1) Enantioselective synthesis of Prozac (Fluoxetine) Synthesis of glycosidase inhibitors He will be a full-time student at Oxy in the fall. Arlene is transferring as a pre-med student to Cal State University, Los Angeles, to major in Biology or Biochemistry.

  9. Synthetic scheme for Prozac

  10. Determination of enantiomeric excess

  11. Revised synthesis of glycosidase inhibitors

  12. Future Synthetic Targets - Naturally occurring antifungal antibiotics - 2,5-disubstituted hydroxy pyrrolidines

  13. What is the feasibility of community college research? What are the benefits for the students? What are the benefits for the instructor? Is there a downside?

  14. Thanks to: 1) The Dreyfus Foundation (summer support for DM) • NSF-REU (summer support for DR) • Ralph M. Parsons Foundation (LACC, NMR purchase) • Petroleum Research Fund (Prozac synthesis) • Cal State, Northridge (Paul Shin): Donation of a polarimeter • William Kaska, UC Santa Barbara: Donation of glassware and argon/vac line

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