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Heavy Magnesium Oxide Suspension. Heavy Magnesium Oxide Rx Heavy magnesium oxide Ʒij Magnesium sulphate Ʒvii Glycerin ℥ i Acacia mucilage ℥ i Peppermint water to ℥ iii Fiat: Mist Sig .: m.d.s . Uses: Laxative. 8 g. 28 g. 30 ml. 30 ml. 90 ml. Label : white.
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Heavy Magnesium Oxide Rx Heavy magnesium oxide Ʒij Magnesium sulphate Ʒvii Glycerin ℥i Acacia mucilage ℥i Peppermint water to ℥iii Fiat: Mist Sig.: m.d.s. Uses: Laxative 8 g 28 g 30 ml 30 ml 90 ml
Label :white Shake The Bottle The Mixture To be taken as directed.
Preparation: Preparation: 1- In a mortar; grind MgSO4 & add MgO mix with pestle 2- Add glycerin & levigate 3- Add acacia mucilage& levigate 4- Transfer to cup measure 5- Adjust volume with peppermint water to 90 ml.
Heavy Magnesium Oxide Rx Heavy magnesium oxide 8gm Magnesium sulphate 28gm Glycerin 30ml Acacia mucilage 30ml Peppermint water to 90ml Heavy MgO Add 8 gm Heavy MgO & 28 gm MgSO4in mortar & grind with pestle Add 30 ml Glycerin & levigate Add 30 ml Acacia mucilage & levigate Continue volume with peppermint water to 90 ml. Transfer to cup measure
Alligation Medial • Used to calculate the “Average Percentage Strength” of mixture of two or more substances whose quantities and concentrations are known.
What is the percentage of alcohol in a lotion containing 1500ml. of witch hazel (14% alcohol), 2000ml. of glycerin, and 5000 ml. of 50% alcohol?
Alligation Alternate • Used to calculate the number of parts of two or more components of a given strength when that should be used to prepare a mixture of desired strength. Percent desired Percent given Parts required
Number of parts of minus gives gives minus Number of parts of a y c b x
Number of parts of minus gives gives minus Number of parts of Example • In what proportion should alcohols of 95% and 50% strengths be mixed to make 270 ml 70% alcohol? 95 20 70 50 25
120 150 270 Mix 120 ml of 95% alcohol with 150 ml of 50% alcohol to produce 270 ml of 70% alcohol.
In what proportion should 20% benzocaine ointment be mixed with ointment baseto produce a 2.5% benzocaine ointment? 2.5 17.5
How many grams of zinc oxideshould be added to 3400 g. of a 10% zinc oxide ointment to prepare a product containing 15% of zinc oxide? 5 85 100% : 10% Parts 5 : 85 grams x : 3400g x= 200 g
A hospital pharmacist wants to use three lots of ichthammol ointment containing respectively 50%. 20%, and 5% of ichthammol. In what proportion should they be mixed to prepare a 10% ichthammol ointment? 5 5 40 + 10 = 50 50% : 20%: 5% 5 : 5 : 50
In what proportion may a pharmacist mix 20%, 15% ,5% , 3% zinc oxide ointment to produce 10% ointment ? 5 7 7 5 OR 10 5 5 10
There are 5 types of problems • Mixing of two different concentrations to produce a third intermediate one (as the previous example) • Dilution: mixing of a solution with concentration x% with the free base where a=x% and b=0% • Concentration: mixing of a solution with concentration x% with the active ingredient where a=x% and b=100% • Mixing of 3 different concentrations. • Mixing of 4 different concentrations.