1 / 10

Disseminated Intravascular Coagulation (DIC)

Disseminated Intravascular Coagulation (DIC). Bryan Imayanagita. Background. Pathological activation Formation of clots throughout the body in the blood vessels Leads to abnormal bleeding; can cause clots that disrupt blood flow to organs Multiple organ failure and death. Causes.

agamemnon-elena
Download Presentation

Disseminated Intravascular Coagulation (DIC)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Disseminated Intravascular Coagulation (DIC) Bryan Imayanagita

  2. Background • Pathological activation • Formation of clots throughout the body in the blood vessels • Leads to abnormal bleeding; can cause clots that disrupt blood flow to organs • Multiple organ failure and death

  3. Causes • Sepsis (most common) • endothelial cell damage (heat stroke, shock) • obstetrical complications • neoplasias • trauma

  4. Pathophysiology • fire/fire extinguisher analogy in normal coagulation • Thrombin (fire) generation at the site of injury • The endothelium (fire extinguisher) expresses antithrombin molecules which will bind to thrombomodulin • No endothelium at damaged tissue site; allows coaguation. Stopped once thrombin reaches healthy tissue. • In DIC, coagulation and anti-coagulation out of balance

  5. Diagnosis • Bleeding from 3 unrelated sites • History of blood loss, hypovolemia • DVT, microvascular thrombosis

  6. Main Features of DIC

  7. Treatment • Determined if patient is bleeding or needs an invasive procedure • If either is positive: fresh frozen plasma or cryoprecipitate can be given • Folic acid • Heparin treatment not established • May not be effective; needs anti-thrombin for anticoagulant activity, reduced by DIC

  8. Prognosis • 10%-50% mortality rate • DIC with sepsis significantly higher than DIC with trauma

  9. Sources • http://www.medstudents.com.br/terin/terin2.htm • http://emedicine.medscape.com/article/779097-overview • http://www.medstudents.com.br/terin/terin2.htm • http://emedicine.medscape.com/article/779097-overview

More Related