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Molly – a newly popular club drug. “Molly” may refer to 2 different drugs. 1. MMDA, the main constituent of Ecstasy 2. TFMPP, a non-controlled synthetic drug with properties similar to Ecstasy, often mixed with other drugs. TFMPP. 1-(3-Trifluoromethylphenyl) piperazine
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“Molly” may refer to 2 different drugs • 1. MMDA, the main constituent of Ecstasy • 2. TFMPP, a non-controlled synthetic drug with properties similar to Ecstasy, often mixed with other drugs
TFMPP • 1-(3-Trifluoromethylphenyl) piperazine • AKA Legal E, Legal X or A2 • An off white powder sold in gelatin capsules, often mixed with other drugs, esp. BZP (benzylpiperazine) • Popular among HS and College students attending Rave Parties • Escalating abuse since 2004 when no longer controlled under CSA
TFMPP Pharmacology • Serotonin releasing agent (like MMDA) • Mild and mellow high • Mild halluinogen • Anti-aggressive • Locomotor inhibition • Hyperthermia • Repiratory depression
However TFMPP seldom sold alone! • Usually mixed with BZP (benzylpiperazine) for its norepinephrine and dopinergic effects. • TFMPP + BZP combo has norepi +dopinergic + serotonin like effects, similar to MMDA • Marketed as a legal Ecstasy • However BZP is controlled under CSA
TFMPP + BZP Side Effects • Tachycardia, hypertension • Insomnia, anxiety • Nausea and vomiting • Headaches, myalgia, hangover • Palpitations and agitation • Seizures (including status) • Rhabdomyolysis, renal failure
Psychosis • Uncommon • More related to BZP than TFMPP • Amphetamine psychosis manifested by hallucinations, delusions and paranoia • Symptoms usually disappear after a few weeks.
Treatment • Supportive • Benzodiazepines • Treat seizures unresponsive to benzodiazepines with phenobarbital
References • http://www.deadiversion.usdoj.gov/drugs_concern/tfmpp.pdf • http://informahealthcare.com/doi/abs/10.3109/15563650.2011.572076 • http://journal.nzma.org.nz/journal/118-1227/1784/ • http://www.toxinz.co.nz/Demo/6/TjA2QkFYWDEwLzAyOA%3D%3D#secrefID0EU6DI • http://www.partyade.com/info.php • http://journal.nzma.org.nz/journal/122-1303/3794/