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Complement

Complement. •Synthesis and attachment of specific antibody to invading microorganisms does not directly lead to destruction . •It is a " label " that identifies them as targets for destruction .

aileen-ramirez
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Complement

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  1. Complement •Synthesis and attachment of specific antibody to invading microorganisms does notdirectly lead to destruction. •It is a "label" that identifies them as targets for destruction. •Microorganisms coated with IgG antibody are more susceptible to phagocytosis by neutrophils and macrophages. •Complement consists of a series of blood proteins, which when activated, lead to lysis of target cells.

  2. macrophage target cell Cytolysis Activation Opsonization Bacteria Phagocytic cell Three Major Biological Activities of Complement Complement

  3. The Complement System •Complement is the term applied to a plasma effector system: --direct mediation of acute inflammatory reactions --destruction of many kinds of cells, bacteria and viruses. •Complement factors has some hormone-like properties: --recruit other humoral and cellular effectors; --inducesdirected neutrophil migration; --triggershistamine release from mast cells; --stimulatesrelease of lysosomal enzymes from PMN's.

  4. Alternative Pathway Classical Pathway C3b, opsonin, substance that “binds” to surface of target cell Assembly of the Terminal Components C5a, anaphylatoxin, act as mediator of local inflammatory response Perforates cell membrane of target cell Complement Pathway(s) C1q-C1r-C1s C3 B C4 D C2 properdin C3 C5 C6, C7, C8 C9 Bacteria, yeast, virus, or tumor cell Antigen-antibody complex recognition unit (C1q-C1r-C1s) activation unit (C4, C2, C3) membrane attack (C5-C9)

  5. Membrane Attack Complex Glycocalyx Lipid bilayer Transmembrane channel Transmembrane channel Micelle “Membrane Attack Complex” (MAC) of Complement

  6. Ag/Ab Complex M’organisms Classical Pathway (Acquired) Alternative Pathway (Innate) A Different “View” of Complement Activation C3 C3b Opsonizing (“coating”) C5 - C9 Terminal Sequence

  7. Ab FcR Y PMN + PMN ++ C3b CR3 Ab FcR +++ Y PMN CR3 C3b Opsonization by C3b Opsonin binding •C3b coatings of cells: --facilitate adherence of bacteria, viruses and other m'organisms to neutrophils, monocytes and macrophages; --facilitate ingestion of certain bacteria by neutrophils and monocytes; --aids ingestion by activated macrophages; --facilitates IgG-induced phagocytosis and cell cytotoxicity.

  8. C3a and C5a MAC (C5-C9) C5a C3b “Actions” of Complement

  9. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Bacterial lysis Phagocytosis Chemotaxis Vasodilation Permeability

  10. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Complement Activation Alternate Pathway C3 and C5 C3b and C5b Membrane attack complex Bacterial lysisPhagocytosis Chemotaxis Vasodilation Permeability

  11. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Complement Activation Alternate Pathway Complement Activation Classical Pathway C3 and C5 C3b and C5b Membrane attack complex C3b Opsonization Bacterial lysisPhagocytosis Chemotaxis Vasodilation Permeability

  12. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Complement Activation Alternate Pathway Complement Activation Classical Pathway C3 and C5 C3b and C5b Membrane attack complex C3a C5a (Anaphalytoxins) C3b Opsonization Bacterial lysisPhagocytosis Chemotaxis Vasodilation Permeability

  13. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Complement Activation Alternate Pathway Mast cell degranulation Complement Activation Classical Pathway C3 and C5 Histamine release C3b and C5b Membrane attack complex C3b Opsonization C3a C5a (Anaphalytoxins) Bacterial lysisPhagocytosis Chemotaxis Vasodilation Permeability

  14. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Complement Activation Alternate Pathway Mast cell degranulation Complement Activation Classical Pathway C3 and C5 Histamine release C3b and C5b Membrane attack complex C3b Opsonization C3a C5b (Anaphalytoxins) Bacterial lysisPhagocytosis Chemotaxis Vasodilation Permeability

  15. Activating Stimuli Microbial Surfaces Ag-Ab Complexes Ag-Ab Complexes Collagen base- Polysaccharides (IgG or IgM) (IgE on Mast cells) membrane (tissue injury) Complement Activation Alternate Pathway Mast cell degranulation Complement Activation Classical Pathway Hageman factor C3 and C5 Coagulation cascade Histamine release Kallikrein Activation Bradykinin C3b and C5b Membrane attack complex C3b Opsonization C3a C5b (Anaphalytoxins) Bacterial lysisPhagocytosis Chemotaxis Vasodilation Permeability

  16. Animations • Complement Animations & Online Quiz • Complement Animations & Quiz

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