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Feedback Inhibition

Feedback Inhibition. Mary McGinty , Kelsey Lorenz McKenzie Merrick, Angelina L iddy. Definition. A metabolic pathway is switched off by the inhibitory binding of its end product to an enzyme that acts early in the pathway . http:// youtu.be/Ph_ZCnW_N_o

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Feedback Inhibition

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  1. Feedback Inhibition Mary McGinty, Kelsey Lorenz McKenzie Merrick, Angelina Liddy

  2. Definition A metabolic pathway is switched off by the inhibitory binding of its end product to an enzyme that acts early in the pathway. http://youtu.be/Ph_ZCnW_N_o http://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120070/bio10.swf::Feedback%20Inhibition%20of%20Biochemical%20Pathways

  3. Characteristics Prevents the cell from wasting chemical resources b/c shuts reaction down Different parts of an enzyme are bonded to by the stopper-changes shape so enzyme is no longer active Repeats: stopper leaves & can be reused

  4. Example • Respiration: • Maintains homeostasis in body • Converts glucose to CO2 and water, forming ATP in the process • When cell has low concentration of ATP(energy), the citric acid cycle feeds the electron transport chain, thus producing ATP • As ATP builds up, citric acid cycle shuts down b/c citric acid is no longer being produced due to citrate synthase

  5. Clinical Case • General hormones • When hormone levels are higher than the set point, feedback inhibitors stop the input into the enzyme so that no more is produced • Hormones are used up—feedback inhibitors re-allow input to the enzyme –creates more to reach set point

  6. Videos http://youtu.be/Ph_ZCnW_N_o http://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120070/bio10.swf::Feedback%20Inhibition%20of%20Biochemical%20Pathways

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