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大區域骨損傷部位再生之新策略

大區域骨損傷部位再生之新策略.

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大區域骨損傷部位再生之新策略

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  1. 大區域骨損傷部位再生之新策略 織工程的三大原則：細胞、間質(matrix) 和組織生長分化因子，其中生長分化因子，居誘導和調控的角色，對細胞的分化、間質之形成有決定性的影響，哈佛大學醫學院血液研究中心主任Dr. Kevy 與 University of Miami, 口腔外科主任 Dr. Marx 多年合作【2,3,9】，發現如以一定劑量的 thrombin 來激發血小板，使之釋出growth factors，如PDGF，TGF-ß，VEGF，EGF等， 會誘導mesenchymal stem cells, endothelial cells及其他細胞發生mitosis , replication 和 differentiation，促進骨組織再生與創傷之癒合，同時亦發現血小板被激化後，所釋出的生長因子量和血小板量是成正比關係，亦即血小板的數目越高，則釋出的生長分化因子也相對越多，從此開啟了利用platelet-rich plasma (簡稱PRP，又稱為platelet concentrate即含有大量血小板的血槳)，來加速骨組織再生與軟組織癒合的研究，因為platelet concentrate來自病人本身，故又稱為 autologous platelet concentrate ( APC)。因PRP血槳內蘊含相當量的 fibrinogen，和thrombin 作用後，會形成 gel 狀之 fibrin-rich matrix，此matrix 不但可以包覆、攜帶骨移植材(bone graft materials)，且可提昇接著性與可塑性，不但有助於創傷的癒合，而且非常適合作為誘導骨組織形成之 scaffold(骨架)，對於未來臨床的應用有相當大的裨益。

  2. New Strategy for Regeneration of A Large Bone Defect • The purpose of this study is to investigate a new bone regenerative material─Biodegradable bioceramic HA containing collagen to achieve tissue regeneration for a large bone defect in the human subjects.Specific aims are listed in the followings:optimization of bioceramic HA-collagen1. Extraction, purification, and reconstitution of collagen2. Surface treatment of HA for enhancing the collagen binding3. Composition of HA bound collagen4. Clinical trials

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