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Original Article Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen

Original Article Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen.

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Original Article Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen

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  1. Original ArticleTestosterone for Low Libido in Postmenopausal Women Not Taking Estrogen Susan R. Davis, M.D., Ph.D., Michele Moreau, M.D., Robin Kroll, M.D., Céline Bouchard, M.D., Nick Panay, M.D., Margery Gass, M.D., Glenn D. Braunstein, M.D., Angelica Linden Hirschberg, M.D., Ph.D., Cynthia Rodenberg, Ph.D., Simon Pack, Ph.D., Helga Koch, Ph.D., Alain Moufarege, M.D., John Studd, M.D., for the APHRODITE Study Team N Engl J Med Volume 359(19):2005-2017 November 6, 2008

  2. Study Overview • In this double-blind, placebo-controlled, 52-week trial among postmenopausal women not receiving estrogen therapy, treatment with a patch delivering 300 mg of testosterone per day resulted in a significant although modest increase in the 4-week frequency of satisfying sexual episodes (1.4 more episodes per month), but the women were also subject to more adverse events, including androgenic side effects

  3. Enrollment and Outcomes Davis SR et al. N Engl J Med 2008;359:2005-2017

  4. Baseline Demographic and Clinical Characteristics of the Patients Davis SR et al. N Engl J Med 2008;359:2005-2017

  5. Four-Week Frequency of Satisfying Sexual Episodes at Week 24 as Compared with Baseline Davis SR et al. N Engl J Med 2008;359:2005-2017

  6. Changes from Baseline in Scores for Domains of the Profile of Female Sexual Function and for the Personal Distress Scale at Week 24 Davis SR et al. N Engl J Med 2008;359:2005-2017

  7. Summary of Adverse Events over a 52-Week Period Davis SR et al. N Engl J Med 2008;359:2005-2017

  8. Conclusion • In postmenopausal women not receiving estrogen therapy, treatment with a patch delivering 300 mg of testosterone per day resulted in a modest but meaningful improvement in sexual function • The long-term effects of testosterone, including effects on the breast, remain uncertain

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