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Alga Extracts as Novel Antiviral Agents

Alga Extracts as Novel Antiviral Agents. By Stephanie Boone. Background. Antimicrobial activity of alga was first reported in 1940 (antibacterial activity of Chorella vulgaris). The antimicrobial properties of seaweed reported in 1951.

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Alga Extracts as Novel Antiviral Agents

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  1. Alga Extracts as Novel Antiviral Agents By Stephanie Boone

  2. Background • Antimicrobial activity of alga was first reported in 1940 (antibacterial activity of Chorella vulgaris). • The antimicrobial properties of seaweed reported in 1951. • Antiviral effects of polysaccarides from marine alga reported to inhibit mumps, and influenza B virus. • 1969 extracts from red algae inhibited HSV and other viruses. • These observations generated little interest due to nonspecificity.

  3. Antiviral Activity Caulerpa taxifolia Inhibited FIV in vitro Blue-green algae (allophycocyanin) Neutralized enterovirus 71 cytopathic effect in vitro Blue-green algae (Cyanovirin-N) Inactivates HIV Spirulina platensis Inhibits HIV activity Spirulina platensis (calcium spirulan) Inhibits HSV-1, human cytomegalovirus (HCMV), measles virus, mumps virus, influenza virus and HIV-1 Alga Sulfated polysaccharides HIV, herpes simplex 1&2, influenza A, RSV, SIV, pseudorabies, bovine herpes and HCMV

  4. Antiviral Mechanisms

  5. My Antiviral Study • METHOD • Grew a lawn of bacteria on TSA plate. • Used bacteria phage assay. PRD-1 was placed in top agar. • Applied Spirulina from health food store to plates in diluted form. • Watched growth over 24 hour period. • Counted plaques.

  6. Study Results • No difference between treated plates and plates not treated. • Assay failed.

  7. Conclusions: Never work with algae in a bottle from the health food store. Study Conclusions

  8. References • Available upon request.

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