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IEG - Arc/Arg 3.1

Genetical strategy for silencing a memory-encoding hippocampal cell assembly. IEG - Arc/Arg 3.1. GFP controlled by Arc/Arg 3.1 gene promoter. Allatostatin receptor (AlstR). + 10 nM Alst. Erasing and re-installing a hippocampus-dependent memory.

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IEG - Arc/Arg 3.1

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  1. Genetical strategy for silencing a memory-encoding hippocampal cell assembly IEG - Arc/Arg 3.1 GFP controlled by Arc/Arg 3.1 gene promoter Allatostatin receptor (AlstR) + 10 nM Alst

  2. Erasing and re-installing a hippocampus-dependent memory

  3. Behavioural protocols and `high-cost decision point´

  4. 14-tetrode microdrive 64 channel Neuralynx Cheetah system Extrafield firing at the high-cost decision point

  5. Nonlocal representations at the choice point preferentially sweep forward of the animal Nonlocal representations at the choice point sweep down the two choices separately

  6. Extrafield firing during error correction

  7. Nonlocal representations are correlated but not defined by the orientation of motion Nonlocal representations occur at locations of highly variable orientation of motion Difference between histograms of reconstruction error distance during samples with variable orientation of motion and during the rest of the session.

  8. High theta power at the choice points, no SW ripples.

  9. Development of nonlocal representations with experience Splitter cells – unindentified extrafield firing of place cells multiple-T task The total amount of nonlocal reconstructed probability decreased In contrast, on the cued-choice task, the forward component of the sweep maintained nonlocality.

  10. Hippocampal reevaluation in spatial navigation behavioral “microchoices” (only the prediction component) hippocampus ventral striatum prefrontal cortex VTE (reward anticipation) (decision making parameters) orbitofrontal cortex (the value of potential choices) “vicarious trial and error” (VTE) behaviors

  11. Thank you for yourattention

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