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Kitten with Pruritis

Kitten with Pruritis. Dennis B. DeNicola, DVM, PhD, DACVP Chief Veterinary Educator IDEXX Laboratories. “Kitten” – 6 month old DSH. 6 months old Intact female Domestic Shorthair Presented with clinical history of pruritis

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Kitten with Pruritis

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  1. Kitten with Pruritis Dennis B. DeNicola, DVM, PhD, DACVP Chief Veterinary Educator IDEXX Laboratories

  2. “Kitten” – 6 month old DSH • 6 months old • Intact female • Domestic Shorthair • Presented with clinical history of pruritis • Cat was depressed upon presentation but became extremely excited during blood collection process

  3. “Kitten” – 6 month old DSH WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0.79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 % HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 % MCV = 39.1 fL LOW ( 41.0 – 58.0 ) RDW = 22.7 % HIGH ( 17.3 – 22.0 ) MCHC = 35.5 g/dL ( 29.0 – 36.0 ) MCH = 13.86 pg ( 12.50 – 17.60 ) PLT = 905 K/L HIGH ( 175 – 600 ) MPV = 16.69 fL PCT = 1.5 % PDW = 17.9 %

  4. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 % MCV = 39.1 fL LOW ( 41.0 – 58.0 ) RDW = 22.7 % HIGH ( 17.3 – 22.0 ) MCHC = 35.5 g/dL ( 29.0 – 36.0 ) MCH = 13.86 pg (12.50 – 17.60)

  5. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 )

  6. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) • Anemia • Mild

  7. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 %

  8. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 % • Anemia • Mild, regenerative

  9. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 % MCV = 39.1 fL LOW ( 41.0 – 58.0 ) RDW = 22.7 % HIGH ( 17.3 – 22.0 ) MCHC = 35.5 g/dL ( 29.0 – 36.0 ) MCH = 13.86 pg (12.50 – 17.60)

  10. “Kitten” – 6 month old DSH Erythron HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 % MCV = 39.1 fL LOW ( 41.0 – 58.0 ) RDW = 22.7 % HIGH ( 17.3 – 22.0 ) MCHC = 35.5 g/dL ( 29.0 – 36.0 ) MCH = 13.86 pg (12.50 – 17.60) • Anemia • Mild, regenerative, microcytic and potential mild anisocytosis

  11. Erythron – Data Interpretation • Anemia • Mild • Microcytic (decreased MCV) • Regenerative (increased Reticulocyte Count) • Potential mild anisocytosis (increased RDW)

  12. Erythron – Blood Film

  13. Erythron – Blood Film

  14. Erythron – Blood Film

  15. Erythron – Blood Film

  16. Erythron – Blood Film

  17. Erythron – Blood Film

  18. Erythron – Blood Film Interpretation • Anemia • Mild • Regenerative - reticulocytosis • Polychromasia • Anisocytosis

  19. Erythron – Blood Film Interpretation • Anemia • Mild • Regenerative - reticulocytosis • Polychromasia • Anisocytosis • Blood loss anemia • Developing Iron deficiency

  20. “Kitten” – 6 month old DSH Leukon WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0..79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 %

  21. “Kitten” – 6 month old DSH Leukon WBC = 17.76 K/L ( 5.50 – 19.50 ) • High normal leukocyte count

  22. “Kitten” – 6 month old DSH Leukon WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0..79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 %

  23. “Kitten” – 6 month old DSH Leukon WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0..79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 % • High normal leukocyte count • Mild monocytosis

  24. “Kitten” – 6 month old DSH Leukon WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0..79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 % • High normal leukocyte count • Mild monocytosis • Low normal lymphocytes in face of excitement !

  25. “Kitten” – 6 month old DSH Leukon WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0..79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 % • High normal leukocyte count • Mild monocytosis • Low normal lymphocytes in face of excitement ! • High normal eosinophils with possible “stress”

  26. Erythron – Blood Film

  27. Erythron – Blood Film

  28. Erythron – Blood Film

  29. Erythron – Blood Film

  30. Erythron – Blood Film

  31. Erythron – Blood Film

  32. Erythron – Blood Film

  33. Erythron – Blood Film

  34. Erythron – Blood Film

  35. Leukogram Interpretation • Normal leukocyte count • No lymphocytosis in face of excitement • Probable underlying glucocorticoid influence (“stress”) • High normal eosinophil count in face of possible glucocorticoid influence (“stress”) • High probability of underlying eosinophilic inflammatory condition

  36. “Kitten” – 6 month old DSH WBC = 17.76 K/L ( 5.50 – 19.50 ) LYM = 2.36 K/L ( 0.90 – 7.00 ) MONO = 1.78 K/L HIGH ( 0.10 – 0.79 ) NEU = 12.29 K/L ( 2.50 – 12.50 ) EOS = 1.29 K/L ( 0.10 – 0.79 ) BASO = 0.05 K/L ( 0.00 – 0.10 ) %LYM = 13.3 % %MONO = 10.0 % %NEU = 69.2 % %EOS = 7.2 % %BASO = 0.3 % HCT = 23.9 %LOW ( 30.0 – 45.0 ) RBC = 6.11 M/L ( 5.00 – 10.00 ) HGB = 8.5 g/dL ( 8.0 – 15.1 ) RETIC = 102.8 K/L %RETIC = 1.7 % MCV = 39.1 fL LOW ( 41.0 – 58.0 ) RDW = 22.7 % HIGH ( 17.3 – 22.0 ) MCHC = 35.5 g/dL ( 29.0 – 36.0 ) MCH = 13.86 pg ( 12.50 – 17.60 ) PLT = 905 K/L HIGH ( 175 – 600 ) MPV = 16.69 fL PCT = 1.5 % PDW = 17.9 %

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