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Why does metabolic stress increase the body’s use of protein as a fuel source?

Why does metabolic stress increase the body’s use of protein as a fuel source?. Caitlyn Whiteside, Sierra Terrel-Perez, Michayla Robertson. Metabolic Stress. Stressors Sepsis/Burns Major surgery/Disease Acute injury Cancer/Inflammation. H ormones Glucagon Cortisol

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Why does metabolic stress increase the body’s use of protein as a fuel source?

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  1. Why does metabolic stress increase the body’s use of protein as a fuel source? Caitlyn Whiteside, Sierra Terrel-Perez, Michayla Robertson

  2. Metabolic Stress Stressors Sepsis/Burns Major surgery/Disease Acute injury Cancer/Inflammation Hormones Glucagon Cortisol Sympathetic Stimulation: Epinephrine Norepinephrine

  3. Hormone Spotlight • Cortisol • Inhibition of glucose uptake by tissues (except brain) • Stimulates protein degradation while hindering protein synthesis • Glucagon • Increases gluconeogenesis process

  4. Amino Acids • Alanine • Primary substrate required for gluconeogenesis, made available to the liver via catabolism of skeletal muscles. • Activated by Cortisol • Glutamine • Goes to GI tract for immunity response

  5. Goal: Glucose Availability

  6. References Biolo, G., Toigo, G., Ciocchi, B., Situlin, R., Iscra, F., Gullo, A., & Guarnieri, G. (2010). Metabolic response to injury and sepsis: Changes in protein metabolism. Nutrition (Burbank, Los Angeles County, Calif.), 13(9 Suppl), 52S-57. doi:10.1016/S0899-9007(97)83044-4 Kim, H. (2011). Glutamine as an immunonutrient. Yonsei Medical Journal, 52(6), 892-897. doi:10.3349/ymj.2011.52.6.892 Nelms, Marcia N, et al. (2011) Metabolic Stress and the Critically Ill: Nutrition Therapy and Pathophysiology. 2nd ed. Belmont: Wadsworth, Cengage Learning. 683+. Print.

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