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Alcohol Research and Health: Preventing and Treating Alcoholism and Alcohol-Related Disorders

Alcohol Research and Health: Preventing and Treating Alcoholism and Alcohol-Related Disorders Ting-Kai Li, M.D. Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health U.S. Department of Health and Human Services September 6, 2006 Washington, D.C.

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Alcohol Research and Health: Preventing and Treating Alcoholism and Alcohol-Related Disorders

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  1. Alcohol Research and Health: Preventing and Treating Alcoholism and Alcohol-Related Disorders Ting-Kai Li, M.D. Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institutes of Health U.S. Department of Health and Human Services September 6, 2006 Washington, D.C.

  2. National Institute on Alcohol Abuse and Alcoholism Mission

  3. Extent of Alcohol-Related Health Problems in the United States

  4. 18 + yrs. - NIAAA NESARC ( Grant, et al., (2004) Drug and Alcohol Dependence, 74:223-234) 12-17 yrs - U.S. Substance Abuse and Mental Health Services Administration 2003 National Survey on Drug Use and Health (NSDUH) Prevalence of Past-year DSM-IV Alcohol Dependence by Age United States, 2001-2002 Prevalence of DSM-IV Alcohol Dependence in 2001-2002 was 3.8%

  5. Heterogeneity of Drinking Behavior: Diagnosis

  6. Treatment of, and Recovery from, Alcohol Dependence

  7. Inherent Heterogeneity of Alcohol Dependence

  8. Heterogeneity of Treatment Populations: Severity

  9. Heterogeneity of Treatment Populations

  10. Updated medications information incorporating the approval of a long-acting injectable form of naltrexone and results from Project COMBINE Medications management support tool kit for non-specialists prescribing medications for alcohol dependence Additional online support including a dedicated web page for the Guide and related resources 2005 Products Helping Patients Who Drink Too Much: A Clinician's Guide Coming Soon http://www.niaaa.nih.gov

  11. FDA Approved Medications for Treating Alcohol Dependence

  12. Multiple Neurotransmitter Systems Involved in Multiple Aspects of Alcohol Use Behavior Yield Multiple Promising Targets

  13. Medications for Treating Alcohol Dependence – Under Investigation

  14. Examples of NIAAA-Supported Clinical Pharmacotherapy Trials for AUDs and Co-morbid Psychiatric Conditions

  15. Personalized Medicine • Improve Disease Phenotyping • risk factor identification • scalable criteria and markers for severity of disease • Improve Understanding of Relationship of Alcohol and Co-occurring Brain Disorders • Pharmacogenomics – genetic variations in response to medications

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