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1. asdf Grand Challenge in Comparative Endocrinology EVOLUTION EVOLUTION EVOLUTION EVOLUTION EVOLUTION EVOLUTION EVOLUTION EVOLUTION RECEPTORS REGULATORY NETWORKS GENES SIGNALING MOLECULES, HORMONES ORGANISM INTERACTIONS GENE PRODUCTS SYNTHESIS & INTEGRATION ENVIRONMENT ENVIRONMENT ENVIRONMENT ENVIRONMENT ENVIRONMENT ENVIRONMENT ENVIRONMENT ENVIRONMENT GENES GENE PRODUCTS RECEPTORS SIGNALING MOLECULES, HORMONES REGULATORY NETWORKS SYNTHESIS & INTEGRATION ORGANISM INTERACTIONS NUTRITION PHYSIOLOGY DEVELOPMENT GENETICS IMMUNOLOGY ENDOCRINOLOGY MORPHOLOGY REPRODUCTION CELL BIOLOGY GENES GENE PRODUCTS SIGNALING MOLECULES, HORMONES REGULATORY NETWORKS RECEPTORS ANIMALS PLANTS PROTISTS FUNGI GENE PRODUCTS GENES ORGANISM INTERACTIONS MICROBES

2. Frontiers in Comparative Endocrinology Identifying and Mapping New Comparative Genomes: Novel Receptors can be identified from where they are annotated as to their sequence and their percent identity Use of gene prediction models; Phylogenetic analysis Receptors of interest can be cloned, expressed and tested for function Compare to newly sequenced genomes Molecular Comparative Endocrinology Comparative Genomes Bioinformatics, genomics GPCR Models Structure-Activity Relationships

3. Example: NOVEL RECEPTORS ARE IDENTIFIED Molecular Biology Bioinformatics MOLECULAR COMPARATIVE ENDOCRINOLOGY: Site-directed mutagenesis Pharmacological Studies Identify binding sites Determine activation, binding sites and signaling pathways Propose new ligand molecules Medical & Therapeutic Development GPCR Models Structure-Activity Relationships

4. Implementation of Grand Challenges in Comparative Endocrinology Discovery of Novel Hormones and Signaling pathways; Discovery of New Pharmaceuticals to treat human disease; Hormonally based strategies for pest control; Development of “Endocrinomics”—high through put analysis Basic, Applied and Therapeutic/Medical Models Support New Key/alternate model organisms in evolution; Mechanisms of Evolution via genome discoveries Research Cooperative Networks Dissemination of Information to public; scientists Comparative Endocinology Comparative Endocrinology Highlight Cutting Edge Discoveries

5. North American Society for Comparative Endocrinology (NASCE) The society will include scientists from Canada, the USA and Mexico. Co-chairs of the organizing committee: Bob Denver, Univ. of Michigan, USA rdenver@umich.edu Vance Trudeau, University of Ottawa, Canada trudeauv@uottawa.ca Purpose: To promote the study of hormones, hormone action in diverse animal species; to foster interdisciplinary collaborations; to promote the development of databases and other research tools for comparative endocrinology; to advocate for funding for comparative endocrinology research The NASCE will become incorporated as a nonprofit organization in the spring of 2010. A website is under development and a solicitation for charter membership will be sent out at this time . Meetings of the NASCE will be held once every two years in the summer, to alternate with meetings of the European Society of Comparative Endocrinologists.

6. Frontiers in Comparative Endocrinology Developmental, Physiology Behavior Neuroendocrine System Organismal Form, Function, Survival Comparative Endocinology CLIMATE CHANGE Comparative Endocrinology Interactions with the Environment