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Andrade et al. - Supplementary Figure 1. A. 10 20 30 40 50 60 70 80 90 100 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|
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Andrade et al. - Supplementary Figure 1 A 10 20 30 40 50 60 70 80 90 100 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| Mus musculus MPQTPPFSAMFDSS-GYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSEGDGD Homo sapiens ..............-................................................................................DP.S. Gallus gallus .......A......-.........K............................S..................................I.Q.....PVQ. Xenopus tropicalis.....TLV......-SFH......K.E..SE...Q.......................................I..S....R...V.M.Q...N.P.L. Danio rerio .......PV.Y..TN...K...KAK.EDYE.........I........E.........................L......S.......DQ....DPQA. 110 120 130 140 150 160 170 180 190 200 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| Mus musculus KNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRMASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKLSSTATDRLTVLKTKPQSIQRDI Homo sapiens .........................................I...................................I...S.................. Gallus gallus ..RI................................E..Q.IT..D.-M.......LL.N.L....TV.........INA.S.................. Xenopus tropicalis.S.V.................................T...ITN.D.-M.......II.N......S.T....LIT.INAQS...M.............. Danio rerio ..RV............................KS..E.T..LST..D-L........T.T.....TT..........IN.SV.................. 210 220 230 240 250 260 270 280 290 300 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| Mus musculus MTVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNI Homo sapiens I...N............................................................................................... Gallus gallus I...N...........................................D...S................................V.............. Xenopus tropicalis I........V............S...................NEN...D...P...................................F........... Danio rerio L.I.N..F..............S.....................N.F.DH..AS...............................V..F........... 310 320 330 340 350 360 370 380 390 400 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| Mus musculus GNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCVNRLPNGHVNF Homo sapiens .................................................................................................... Gallus gallus ........................................................T........................................... Xenopus tropicalis.................................................................N........C..............TS......... Danio rerio ..........T.............................................T...I....................................... 410 420 430 440 450 460 470 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|.... Mus musculus EKFWELAKQVSEFMTWKQVECPFERDRKVLQYLLSVPVFSEDALYLASYESEGPENNIEKDRWKSLRSSLLGRV Homo sapiens ............................I.....T.....................H................. Gallus gallus ............................I.....TI....D...........S...H.......T...T..... Xenopus tropicalis ........................K...I.H.V.T..I..................H.......T...A..... Danio rerio ..........T......K.....D....I.....T......................M.............N.T B C