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Mendelian Exceptions. 1.31.13. Mendelian Exceptions. Mendel got lucky – all 7 traits he studied showed complete (simple) dominance . Mendelian Exceptions. Mendel got lucky – all 7 traits he studied showed complete (simple) dominance .
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Mendelian Exceptions 1.31.13
Mendelian Exceptions Mendel got lucky – all 7 traits he studied showed complete (simple) dominance.
Mendelian Exceptions • Mendel got lucky – all 7 traits he studied showed complete (simple) dominance. • One allele is completely dominant over the other allele • Homozygous dominant and heterozygous = same phenotype • 1 allele is enough for full expression of dominant trait
Incomplete Dominance = the norm Heterozygote = intermediate phenotype 1 allele is not enough for full expression
Incomplete Dominance • Ex: flower color • R = red RR xrr • r = white
Incomplete Dominance F2: RrxRr
Incomplete Dominance Rr 1 red 2 pink 1 white Rr Rr Rr F2: RrxRr Alleles not blended – still able to separate.
Codominance – Both alleles are expressed equally • Ex: Cows • B = black • W = white • BB = Black • WW = White • BW = ???
Codominance – Both alleles are expressed equally • Ex: Cows • B = black • W = white • BB = Black • WW = White • BW = Black and white • Other examples: calico cats, zebras, streaked flowers…
Multiple alleles • Allele: Alternate forms of a gene • Only 2 possible alleles in an individual, BUT any # of alleles may be present in a population due to mutations
Blood Types (ABO blood types) Example of simple dominance, codominance, and multiple alleles
Blood Types (ABO blood types) • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B BO • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B BO B • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B BO B AB • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B BO B AB AB (codom.) • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B BO B AB AB (codom.) OO • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Blood Types (ABO blood types) Genotype Phenotype AA A AO A BB B BO B AB AB (codom.) OO O • Example of simple dominance, codominance, and multiple alleles • Alelles = A, B, O • A & B = Dominant • O = Recessive
Q: What combination of parents have an equal chance of having any of the 4 blood types?
Q: What combination of parents have an equal chance of having any of the 4 blood types?
Mexican Hairless Dogs • Hairless (H) is completely dominant over hairy (h). • When two hairless are crossed: • 2/3 hairless • 1/3 hairy Why???
Mexican Hairless Dogs • Hairless (H) is completely dominant over hairy (h). • When two hairless are crossed: • 2/3 hairless • 1/3 hairy
Lethal Allele 2 copies of a lethal allele = death (usually stillborn) Hint: if offspring ratio is x/3, think lethal allele (someone is dying)
Lethal Allele Q: How can we breed hairless dogs without stillborns?
3, 4, 5, etc. trait crosses If a pea plant that is TTRrPp is crossed with a plant that is TtrrPp, what percent of the offspring will be heterozygous for all three traits?
If a pea plant that is TTRrPp is crossed with a plant that is TtrrPp, what percent of the offspring will be heterozygous for all three traits? Is there an easier way???
Product Rule Make a simple 4 square cross for each trait, then multiply the results for each
Epistasis • The process of one gene controlling the expression of another • An epistatic gene can completely mask the effects of another gene • 2 genes -> 1 trait
Example: Hair Color • 2 genes are responsible for hair color: • black-brown gene • red-blonde gene
Example: Hair Color • 2 genes are responsible for hair color: • black-brown gene • red-blonde gene • Black-brown is epistatic(dominant) over the red-blonde gene • Two “exceptions” present – incomplete dominance and epistasis
-> controls -> • R = red • r = blonde • B = black • b = brown
-> controls -> • R = red • r = blonde • B = black • b = brown • BB__ =
-> controls -> • R = red • r = blonde • B = black • b = brown • BB__ = black
-> controls -> • R = red • r = blonde • B = black • b = brown • BB__ = black • Bbrr =
-> controls -> • R = red • r = blonde • B = black • b = brown • BB__ = black • Bbrr = brown
-> controls -> • R = red • r = blonde • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ =
-> controls -> • R = red • r = blonde • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn
-> controls -> • R = red • r = blonde • bbRR = • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn
-> controls -> • R = red • r = blonde • bbRR = red • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn
-> controls -> • R = red • r = blonde • bbRR = red • bbRr = • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn
-> controls -> • R = red • r = blonde • bbRR = red • bbRr = strawberry blonde • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn
-> controls -> • R = red • r = blonde • bbRR = red • bbRr = strawberry blonde • bbrr = • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn
-> controls -> • R = red • r = blonde • bbRR = red • bbRr = strawberry blonde • bbrr = blonde • B = black • b = brown • BB__ = black • Bbrr = brown • BbR_ = auburn