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Nanocell

Nanocell. Intro of Drug Delivery System What is nanocell Marketing Ethics Mechanism Ms. Soraya Synthesis Ms. Titima In vivo In vitro Dr. Panthee Clinical trial Summary . Ms. Chanokkamon. Dr. Bonduush. Nanocell:. Introduction, Marketing part and Ethical issues.

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Nanocell

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  1. Nanocell • Intro of Drug Delivery System • What is nanocell • Marketing • Ethics • Mechanism Ms. Soraya • Synthesis Ms. Titima • In vivo In vitro Dr. Panthee • Clinical trial • Summary Ms. Chanokkamon Dr. Bonduush

  2. Nanocell: Introduction, Marketing part and Ethical issues Ms Chanokkamon Cheawtada Inter-U program AIT

  3. Scope: Marketing and Ethics • Drug delivery system • General cancer • Liver cancer treatment • Conventional drug for treat liver cancer • Problems of conventional drug • What is “nanocell”? • Advantage of nanocell • Compare cost-benefit between conventional drug and nanocell • Using Calculation for profit cost for developing country (Ethics)

  4. Drug delivery system for cancer • Drug targeting of tumors • Maximize drug potency • Minimize systemic toxicity. • Drug carrier Route of administation • ●Liposome • composed of one or more phospholipid bilayer Intravenous(iv)injection • e.g. liposome entrapped doxorubicin • ●Bead • e.g. drug-eluting microspheres/beads Hepatic artery • (DEB) load with doxorubicin • ●Prodrug • e.g prodrug of cisplatin using dextran Intravenous(iv)injection • (galactose unit)

  5. Liver cancer treatment Liver cancer Localized unresectable Localized resectable Segmental resection - Trisegmental resection liver transplantation Systemic chemotherapy Tumor embolization Chemoembolization Hormone therapy Radiolabeled Recurrent

  6. Conventional drugs • . Doxorubicin IV injection 60-90 mg/m2- every 3 weeks 20-30 mg/m2/day - 3 days every 3 to 4 weeks. Dose depends upon which regimen for cancer is being Poor risk patient Reduce dosage IV infusion 60-75 mg/m2 - every 3 weeks From http://asia.mims.com, http://www.rxmed.com

  7. Conventional drugs 5-FU IV injection 400 mg/m2 every 5 days repeated every 4 weeks (28-day) Oral (capecitabine) 1250 mg/m2 twice daily 2 weeks 1 week rest From http://asia.mims.com, http://www.rxmed.com

  8. Conventional drugs Cisplatin IV infusion 50-100 mg/m2 every 3-4 week 15-20 mg/m2 daily for 5 days/week for 3-4 week. From http://asia.mims.com, http://www.rxmed.com

  9. Conventional drugs Combretastatin IVinfusions 52 mg/m2 On day 1, 8, and 15. courses repeat every 28 days From: http://www.jco.org

  10. Problem of conventional drug • Many side effect - Drug effect on normal cell e.g. acute nausea, vomiting, mucositis, anorexia, diarrhea, • Less effective - Drug cannot get into only liver but effect other organ • Too complicate in treatment - For treat liver cancer use series of drug for more effectiveness • Series of drug - take time for inject the drugs - very painful because use large dose • Expensive • Drug resistance

  11. From:http://www.medicalillustrator.com

  12. Nanocell • Nanocell is small particle between 10-1000nm. - less than 200 nm. - Can pass through tumor blood vessels - The outer shell anti-angiogenesis - The inner core chemotherapy drugs. - A "stealth" surface - avoid immune system

  13. From:http://www.medicalillustrator.com

  14. From:http://www.medicalillustrator.com, http://www.3d4medical.com

  15. Advantages of Nanocell • Directly to the target site ( liver cancer) • Less side effect - Not effect on normal cell • Not complicate for treatment - Inject only one time in one cycle of treatment • More effective • Less invasive - less pianful - less injection time • Economic price • Easy to inject - IV injection

  16. Compare Cost-benefit http://www.etonbio.com, http://www.hon.ch/News/HSN/527057.html,http://www.biotrend.com,https://www.sigmaaldrich.com, http://www.rocheusa.com

  17. Calculation profit

  18. Ethical issues • Liver cancer population - high incidence in Asia. • Almost countries in Asia are - developing countries • Almost developing countries have - a large number of poor people e.g. Thai GDP per capita income 2,221 US$ • “Nanocell for developing countries” - economic price

  19. Nanocell for developing countries 11,868 persons 1995 – 1997 Sriamporn, et al(2002)

  20. Summary • So nanocell has been made for solving those problems of the conventional drugs • For its price, there are two target groups which are: - the developing countries such as Thailand, Indonesia , it will be sold at whole sale - the other countries at the retail.

  21. Addition Body surface area in m2 = √ { height (cm) x weight (kg) }/3600 = 1.845 m2 Standard WHO wieght 70 kg Hight 1.75 metre (from Norgan 1994)

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