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Mäithé Tauber and Thomas Edouard Toulouse, France

Prevalence of Primary Insulin-like Growth Factor-I deficiency in prepubertal children with short stature. Mäithé Tauber and Thomas Edouard Toulouse, France. Barcelona May 2009. Aims of the study.

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Mäithé Tauber and Thomas Edouard Toulouse, France

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  1. Prevalence of Primary Insulin-like Growth Factor-I deficiency in prepubertal children with short stature MäithéTauber and Thomas Edouard Toulouse, France Barcelona May 2009

  2. Aims of the study To review all children with SS seen in our Paediatric Endocrinology Unit from January 2005 to December 2007 To evaluate the prevalence of non-GH deficient IGFD in prepubertal children with SS and to describe this population

  3. Inclusion criteria: Short stature with current height SDS below or equal to -2.5 Age  2 years Prepubertal status Exclusion criteria: Identified cause of short stature Current or past therapy with rhGH

  4. Screening process to identify patients with primary IGFD In 2005, 2006, 2007short stature < -2 SDS Girls: 2-13 years, boys: 2-14 years n=362 Height> -2.5 SDS (n=217) Pubertal patients (S2 or G2) (n=54) Syndromes or chromosomal defects (n=17) Bone diseases (n=7) Severe neurological impairment (n=10) Severe chronic illness (n=5) Prepubertal children withshort stature < -2.5 SDS (n=65) n=65

  5. Screening process to identify patients with primary IGFD Prepubertal children withshort stature < -2.5 SDS (n=65) n=65 Growth hormone deficiency (n=19) IGF-I > -2SDS Primary IGFD (n=13) AGA n=9 and SGA n=4 20% PIGFD

  6. Frequency of primary IGFD in 65 children with SS GHD SGA IGFD IGFD ISS GHD 19 29% ISS34% 13 20% SGA37% 17% PIGFD 20 31% 40% PIGFD 9 14% 4 6% PIGFD20%

  7. Classification and frequency of GH-IGF-I axis abnormalities Normal 51%

  8. Auxological, hormonal characteristics and complementary studies of the 13 children with PIGFD IGF generation testa * Molecular studies of GHR were undertaken in three patients (number 2, 6 and 8) and were normal.

  9. Conclusion The prevalence of primary IGFD was 20% in the children with short stature 30% of them are born SGA Need for extensive multicentre studies to identify patients with Primary IGFD  EPIGROW

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