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THE EFFECT OF LYCOPENE ON CHRONIC OBSTRUCTIVE LUNG DISEASE

THE EFFECT OF LYCOPENE ON CHRONIC OBSTRUCTIVE LUNG DISEASE. Gamze Kırkıl, Mehmet Hamdi Muz, Enver Sancaktar, Dilara Kaman, Kazım Şahin, Ömer Küçük. The importance of oxidative stress in the pathogenesis of COPD which is termed as a chronic inflammatory disease is known

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THE EFFECT OF LYCOPENE ON CHRONIC OBSTRUCTIVE LUNG DISEASE

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  1. THE EFFECT OF LYCOPENE ON CHRONIC OBSTRUCTIVE LUNG DISEASE Gamze Kırkıl, Mehmet Hamdi Muz, Enver Sancaktar, Dilara Kaman, Kazım Şahin, Ömer Küçük

  2. The importance of oxidative stress in the pathogenesis of COPD which is termed as a chronic inflammatory disease is known • An imbalance in the oxidant-antioxidant system has been recognised as one of the first events that lead to inflammatory reactions in the lung • Oxidative stress causes the activation of proinflammatory cytokines and chemokines

  3. As a natural antioxidant, lycopene is associated with the prevention of some chronic diseases including cardiovascular diseases and gastrointestinal tract and prostat cancers in the human • Any study that addresses the effect of lycopene on oxidative stress in COPD is not found

  4. Aim • To investigate the effect of lycopene on oxidant stress in COPD patients • To evaluate the changes that may be occur in pulmonary function tests (PFT) parameters after lycopene supplementation

  5. Materials and Methods • Thirty male patients with clinically stable, stage III COPD, and 15 healthy non-smoker subjects were enrolled on the study • COPD patients randomly divided into two groups • One group (n=15) received oral placebo for 4 months addition to their standardized therapy. • The other group (n=15) received 20 mg lycopene daily for 4 months addition to their standardized therapy.

  6. Baseline pulmonary function tests were applied to all cases • Serum malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), interleukin (IL)-6, IL1β, and tumor necrosis factor alpha (TNF-α levels) levels of all cases were measured • PFT, MDA, SOD, CAT, IL-6, IL1β and TNF-α measurements were repeated after lycopene supplementation

  7. Results • There was no difference between COPD patients and controls in age and sex distribution • No significant difference was observed between COPD groups in demographic characteristics and PFT parameters

  8. Table 1. Demographic characteristics and PFT parameters of COPD patients

  9. Serum MDA, IL-6, IL-1β, and TNF- α levels of COPD patients were significantly higher, serum SOD, and CAT levels were significantly lower than control group (for all, p<0.05)

  10. Table-2: Comparison of oxidative and inflammatory marker levels in both COPD and control groups

  11. Serum SOD and CAT levels of COPD group which received lycopene supplementation increased significantly when compared with baseline values • Lycopene supplementation was associated with a significant decrease in mean MDA, IL-6, IL-1β, and TNF- α levels • A significant increase was seen in FEV1/FVC (%) parameter, and an increase that is not reached statistically significance in FEV1 (% pred) was observed

  12. Table-3: Effects of Lycopene supplementation on oxidant-antioxidant, inflamatory, and pulmonary function parameters

  13. Discussion • Oxidative stress and imbalance in the host defense mechanisms is important in COPD pathogenesis • The results of studies of antioxidant enzyme activities in smokers have been controversial • We found that plasma levels of SOD and CAT decreased in COPD group when compared to controls. This may point towards the fact that increased production of free radicals leads to increased consumption of antioxidant enzymes.

  14. It is known that MDA, an end product of lipid peroxidation, can be used as a marker of oxidative stress • There have been many studies showed that MDA levels increased in COPD patients when compared to healthy controls

  15. It is known that proinflammatory cytokine levels released by neutrophil, macrophage, and CD8 T lymphocytes are increased in COPD patients

  16. In the studies which investigate the roles of anioxidants in COPD therapy and prevention, vitamin C, and vitamin E used, and it is shown that lung functions are better in antioxidant therapy group • The studies investigating the effect of lycopene supplementation on oxidative stres showed a significant inhibition of the infiltration of inflammatory cells, decrease in proinflammatory cytokin levels, and depression on oxidant stress in lycopene treated groups

  17. Conclusion • Lycopene supplementation may have favourable effects on oxidant-antioxidant balance in patients with COPD • Longer duration of supplementation may be necessary to observe more clinical benefit

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