1 / 14

T-cell lymphoma

T-cell lymphoma. A. Precursor T-cell lymphomas T-acute lymphoblastic leukaemia T-lymphoblastic lymphoma B. Mature T-and NK cell neoplasms uncommon –10% of all NHL Most frequent : peripheral T-cell lymphoma, unspecified large cell anaplastic lymphoma. Most common T-cell lymphomas.

alexis
Download Presentation

T-cell lymphoma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. T-cell lymphoma A. Precursor T-cell lymphomas • T-acute lymphoblastic leukaemia • T-lymphoblastic lymphoma B. Mature T-and NK cell neoplasms • uncommon –10% of all NHL • Most frequent : peripheral T-cell lymphoma, unspecified • large cell anaplastic lymphoma

  2. Most common T-cell lymphomas 1. Leukaemic/disseminated adult T-cell leukaemia - HTLV 1 2. cutaneous - mycosis fungoides, Sezary syndrome, primary cut. anaplast. lymphoma 3. other extranodal - extranod. NK/T - nasal, enteropathy assoc. 4. nodal - peripheral T-cell lymphoma, NOS, anaplastic large cell lymphoma

  3. Leukaemic • T LGL indolent • ATLL • LA., PB, variants

  4. Mycosis fungoides • Most common cutaneous T-cell lymphoma • middle aged to elderly – males (M:F 2:1) • Protracted • Scaly rash, localized, trunk • Clinical appearancePatches, plaques, tumours, generalized erythroderma • Sezary syndrome: gen. erythroderma, lymphadenopathy, PB involvement

  5. Mycosis fungoides • Indolent • Skin targeted therapy • Chemotherapy for advanced stage

  6. NK/T-cell lymphoma of nasal type • EBV, angiocentric, destructive • South America, Asia Lethal midline granuloma: NK/T-cell l. Wegener granulomatosis Cocaine abuse

  7. coeliac sprue (adults) intestinal perforation intraepitelial T-lymphocytes bad prognosis Enteropathy associated T-cell lymphoma

  8. Enteropathy-associated T-cell lymphoma Proximal jejunum Very rare x most common GI T-cell lymphoma • Acute abdomen (40%) – emergency surgery Obstruction/perforation, peritonitis, sepsis, death • Non-acute: pain, weight loss, malabsorption Age 60, M=F

  9. Enteropathy-associated T-cell lymphoma Multifocal ulcers

  10. Enteropathy-associated T-cell lymphoma Striking association with celiac disease Histology and immunomorphology • Anaplastic/pleomorphic (80%) Celiac dis.+, enteropathy +, CD56- • Monomorphic (20%) Celiac dis.-, enteropathy+/-, CD56+ Half of the patients die soon after the manifestation

  11. Enteropathy-associated T-cell lymphoma CD3 T-cells, plasma cells, eosinophils Anaplastic

  12. TCR gamma - PCR ABI PRISM TGGE Enteropathy assoc. T-cell lymphoma CGH marker: 9q gain (70%; Zettl 2007)

  13. Peripheral T-cell lymphoma, NOS • Lennert lymphoma • Angioimmunoblastic T-cell lymphoma

  14. Anaplastic large T-cell lymphoma • Anaplastic, pleomorphic cells • Hallmark cells, horseshoe-shaped nuclei • CD30, EMA, cytotoxic granule-associated proteins • ALK (ALCL kinase) !SYSTEMIC x CUTANEOUS! Variants Common Lymphohistiocytic Small cell

More Related