1 / 14

Presented by: Yvonne Pao October 24, 2008 Bi 217

Interoception: the sense of the physiological condition of the body Craig, AD. Current Opinion in Neurobiology . 2003, 13:500-505. Presented by: Yvonne Pao October 24, 2008 Bi 217. Introduction to Interoception. Craig, AD 2002. A Homeostatic Afferent Pathway.

alika
Download Presentation

Presented by: Yvonne Pao October 24, 2008 Bi 217

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Interoception: the sense of the physiological condition of the bodyCraig, AD. Current Opinion in Neurobiology. 2003, 13:500-505. Presented by: Yvonne Pao October 24, 2008 Bi 217

  2. Introduction to Interoception Craig, AD 2002

  3. A Homeostatic Afferent Pathway • Neural processes that regulate homeostasis require afferent input from the body • Parasympathetic: afferents to nucleus of solitary tract (NTS) • Sympathetic: Aδ and C fibers to lamina I

  4. Aδ and C Fibers Purves, et al. 2nd edition

  5. Aδ and C Fibers in Lamina I Craig, AD 2003

  6. Lamina I Projections Craig, AD 2002

  7. Lamina I Projections

  8. Primates: Lamina I projects to VMpo

  9. Thermosensory Insula Activation

  10. Primates: Lamina I projection to MDvc

  11. Overall Network of Interoception in Primates

  12. Homeostatic Emotions • In primates: direct activation of interoceptive cortex and ACC by lamina I  Generation of both sensation and motivation • Brooks, et al. 2002: activation of interoceptive cortex by noxious heat  strong activation of right anterior insula if subject looks at painful stimulus • Meta-representation of interoceptive state • Incorporation of sensuous (light) touch in interoceptive system

  13. Conclusions • Interoceptive system distinct from exteroceptive system (cutaneous mechanoreception and proprioception) • Primary interoceptive representation in dorsal posterior insula creates feelings from body including: • Pain • Hunger • Thirst • Temperature • Direct homeostatic inputs to insula and ACC identify peripheral and central afferent complement to efferent autonomic nervous system • Differentiates primates from non-primates • “Feeling self” differentiates humans from non-human primates

  14. Conclusions and Further Work • Endogenous homeostatic control mechanisms modulate the afferent activity that produces feelings from the body • Dependence of well-being on the body • Opponent processing between parasympathetic and sympathetic afferents may lead to differences between “diffuse” and “distinct” feelings • Mutual inhibitory action may be necessary for maintaining control of processes in the gut  This issue deserves intense study because of potential clinical significance

More Related