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Caliciviridae – Feline and Porcine

Caliciviridae – Feline and Porcine. Feline Calicivirus – FCV infection One of two major causes of resp. dz. In kittens, (feline herpesvirus 1is the other) Worldwide Etiologic agent – Feline Calicivirus

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Caliciviridae – Feline and Porcine

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  1. Caliciviridae – Feline and Porcine • Feline Calicivirus – FCV infection • One of two major causes of resp. dz. In kittens, (feline herpesvirus 1is the other) • Worldwide • Etiologic agent – Feline Calicivirus • Multiple serotypes, extensive cross protection, allowiong fo rht esue of monlotypic vaccines, vaccine may not fully prodtect against all strains of FCV • Different strains of FCV – vary in virulence • Some associated with sublicincal infection of URT • Highly virulent stains produce pneumonia – young kittens esp. • Limping syndrome – lameness- some strians with or without oral or resp. dz. • Macs harbor in synovial disease

  2. FCV • Stability – • FCV can persist for up to a week in a damp environment • Transmission – • Natural routes, nasal, oral and conjunctival • Persists in tonsillar ad othe roropharyngeal tissues – persistent infection ans shed virus MORE OR LESS CONTINUOUSLY IN SALIVA FOR MONTHS OR YEARS – LIFE (minority) • Pathogenesis – replication occurs in the oral and respiratory tissues • Mostly confined to the oral cavity, respiratory tract and eyes • ORAL ULCERS ARE THE MOST PROMINENT SIGN

  3. FCV • Pathogenesis continued – • In infections with highly virulent strains, there may be pulmonary edema and interstitial pneumonia • Clinical signs – diesease is rare in cats older than one year of age • Acute infeciton – IP 3-6 days • Course – 1-3 weeks or longer • Fever, ulcers, hypersalivation, mild conjunctivitis, ocular nad nasal discharges • Coinfection with an immunosuppressive virus such as FELV, FIV may further increase the susceptibiliy to disease of individual cats

  4. Pathogenesis for Feline Calicivirus

  5. Vesicular Exanthema of Swine • So. Californai • Still endemic in sea lions • VE indistinguishable form foot and mouth disease • Swine vesicular dz,vesicular stomatitis • San Miguel Sea Lions Virus • Abortion, and vesicular lesions of the flippers • Produced lesions similar to VE lesions in experimentally infected swine • Reservoir population of the vesicular exanthema virus

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