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Clinical Characteristics of the Saguenay–Lac-St-Jean Familial Collection Subjects. Abbreviation used: FEV 1 = Forced expiratory volume in one second, PC 20 = Provocative concentration of methacholine that induces a 20% fall in FEV 1 , SD = Standard deviation.
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Clinical Characteristics of the Saguenay–Lac-St-Jean Familial Collection Subjects Abbreviation used: FEV1 = Forced expiratory volume in one second, PC20 = Provocative concentration of methacholine that induces a 20% fall in FEV1, SD = Standard deviation. * Geometric mean calculated for 218 probands, 325 affected relatives and 440 unaffected relatives **Geometric mean of the log-transformed PC20 calculated for 193 probands, 285 affected relatives and 418 unaffected relatives Madore et al. 2008. Human Genetics
Phenotype Definition Based on the American Thoracic Society and the Canadian Asthma Consensus guidelines * 52 % * 55 % * 63 % * 62 % * Proportion in sample
Available Environmental Data • Occupational Exposures • Domestical Exposures • Carpets (including bedroom) • Pets • Smoking Status (past, present / passive exposure) • Personal respiratory infection documented • Personal health history • Personal type of allergy (indoor or outdoor) • Treatment for asthma
Genealogies parameters in the Saguenay–Lac-St-Jean Familial Collection Subjects