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Silver-haired Bat ( Lasionycteris noctivagans). Vector of cryptic rabies virus 1990-2002: ~70% of 33 reported human rabies cases in the US Only 2 cases had a history of bat bite. Plant System For High-Yield Production of Recombinant Subunit Vaccines. Vaccine Production in Plants. Safety
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Silver-haired Bat(Lasionycteris noctivagans) • Vector of cryptic rabies virus • 1990-2002: ~70% of 33 reported human rabies cases in the US • Only 2 cases had a history of bat bite
Plant System For High-Yield Production of Recombinant Subunit Vaccines
Vaccine Production in Plants • Safety • Cost-efficiency • Easy scale-up • Proper glycosylation • Suitable for developing countries • Possible direct delivery
RABIES VIRUS NEUTRALIZING TITERS OF HUMAN SERA EXPERIMENTAL CONTROL
BIOMEDICALS FOR DISEASE PROPHYLAXIS AND TREATMENT EXPRESSED IN PLANTS AT THE BIOTECHNOLOGY FOUNDATION LABORATORIES
COMPARATIVE COSTS OF ANTI-RABIES ANTIBODIES COMPANYPRODUCTPRODUCT DESCRIPTION PRODUCT PRICE NAME SOURCE Bayer BayRab Human human anti-Rabies 1500 iu $1,125. Donors immunoglobulins Aventis IMOGAM Human anti-Rabies 1500 iu $ 847. Rabies-HT Donors immunoglobulins wholesale (10-18% protein) price AbCam ab10014 Mouse monoclonal mouse 100 µg $ 250. Cells antibodies BiotechnologyMAb57 Tobacco monoclonal mouse 100 µg $ 0.5 -$1. Foundation, Inc.