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Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage

Nimesulide tablet is a widely prescribed anti-inflammatory analgesic drug belongs to BCS class II which is required for the quick treatment of severe muscular pains and inflammatory problems.

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Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage

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  1. Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage

  2. Contents • Introduction • Chemical Formulation • Properties of Nimesulide • Clinical Study • Benefits • Dosage • Conclusion • Disclaimer

  3. Introduction Nimesulide ( Nise 100mg ) is • an NSAID ( Non-steroidal Anti-inflammatory Drugs) • a preferential COX II inhibitor • a multi-factorial mode of action • a analgesic drug • a antipyretic drug Fg.1: Nise 100 mg

  4. Chemical Formulation • Chemical Formula: C13H12N2O5S. • Chemical Name : 4-nitro-2-phenoxymethanesulfoanilide and • belongs to BCS category II. • exhibit low and variable oral bioavailability. • may be a selective Cox-2 anti-inflammatory drug. • by-product of p-nitrophenyl methane series sulfa. • belongs to selective COX-2 inhibitors. Fg.2:Structure of Nimesulide

  5. Properties of Nimesulide 1.Pharmacokinetic: • acts as an aggressive inhibitor of histamine discharge in-vivo and in-vitro. • antihistaminic and anti-allergic properties. • Gastro-duodenal symptoms. • beginning of pain relieving and antipyretic activity: is 1.6– 3.17 h and the term of activity is 10– 12 h. 2. Absorption: • It is well absorbed from the GI tract following oral intake. 3. Pinnacle Plasma Levels: • PPL: 1-3 hours. • the study state is accomplished in 24 to 36 hours ( Offer administrator of 100 mg).

  6. Clinical Study • Nimesulide's remedial incentive in viable and quickly controlling aggravation and agony is bolstered by indispensable clinical proof. • The drug prescribed is supposed to be suitable when the advantage can give to a specific patient exceed the dangers related to its utilization. • Hence, a cautious examination of individual hazard factors is along these lines of urgent significance.

  7. Benefits of Nimesulide Nimesulide 100mg treats: • Headache, back pain, Sprains and strains. • intense pain and primary dysmenorrhoea. • fascinating results by acting quick and fast effects. • No facet effects andgastro-duodenal symptoms. • Rheumatic inflammatory disease, degenerative joint disease, alternative chronic joint disorders treatment. • Musculoskeletal disorders, Thrombophlebitis and Cancer. • Agonizing degenerative joint pains.

  8. Nimesulide Dosage • Adults: 100 mg twice daily after meals. • Children: 5 mg/kg of body weight in 2 or 3 divided doses. • The minimum effective dose should be used for the shortest duration to reduce the undesirable effects. • The maximum duration of a treatment course with Nimesulide is 15 days.

  9. Conclusion • Analgesics form a key part of a treatment, where pain and inflammation is experienced. • Nimesulide well known for its analgesic or pain-relieving properties. • Offers the aforementioned benefits and the drug’s effectiveness. • Therefore, Nimesulide is widely used to treat ailments causing acute pain.

  10. Disclaimer All content in this presentation, including text, images, audio, or other formats were created for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this Website.

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