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HPV

HPV. Human Papillomavirus. Electron Micrograph of HPV Particles. http://www.york.ac.uk/depts/biol/units/cru/hpv.htm. Diagram of Genes in HPV. http://upload.wikimedia.org/wikipedia/commons/8/81/Hpv16b.gif. What each gene does specifically. E1 Initiation of DNA replication

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HPV

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  1. HPV Human Papillomavirus

  2. Electron Micrograph of HPV Particles http://www.york.ac.uk/depts/biol/units/cru/hpv.htm

  3. Diagram of Genes in HPV http://upload.wikimedia.org/wikipedia/commons/8/81/Hpv16b.gif

  4. What each gene does specifically • E1 Initiation of DNA replication • E2 Transcriptional regulation/DNA replication • E3 ? • E4 Disrupts cytoskeleton? • E5 Transforming protein, interacts with growth factor receptors • E6 Transforming protein, binds to p53, leading to degradation • E7 Transforming protein, binds to pRB E8 ? • L1 Major capsid protein • L2 Minor capsid protein

  5. HPV

  6. How HPV grows From Beutner, KR et al, "Human Papillomavirus and Human Disease." Am J Med 1997; 102(5A):9-15.

  7. Cycle of genes in HPV when activated

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