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Wednesday June 27. 2012 Cheryl Jennings, Bria Dawson, Even Skjervold , & Kali Luffy

Periocular Drug Delivery. Wednesday June 27. 2012 Cheryl Jennings, Bria Dawson, Even Skjervold , & Kali Luffy. Overview. Casted two films with FDA Completed calibration curves for FDA Tested solvents for both drugs Casted 4 films; two for ganciclovir and two for valganciclovir

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Wednesday June 27. 2012 Cheryl Jennings, Bria Dawson, Even Skjervold , & Kali Luffy

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  1. Periocular Drug Delivery Wednesday June 27. 2012 Cheryl Jennings, Bria Dawson, Even Skjervold, & Kali Luffy

  2. Overview • Casted two films with FDA • Completed calibration curves for FDA • Tested solvents for both drugs • Casted 4 films; two for ganciclovir and two for valganciclovir • Started drug release study for FDA

  3. Concentration : 1-10 µg/ml FDA Serial Dilution 1 FDA Serial Dilution 2 S/N=809.74 S/N values are not available

  4. Concentration : 0.1-1 µg/ml FDA Serial Dilution 1 FDA Serial Dilution 2 S/N=656.91 S/N values are not available

  5. Concentration : 0.1-0.01 µg/ml FDA Serial Dilution 1 FDA Serial Dilution 2 S/N=12.08 S/N values are not available

  6. Concentration : 0.01-0.001 µg/ml FDA Serial Dilution 1 FDA Serial Dilution 2 S/N=317.29 S/N values are not available

  7. Solvent study for Ganciclovir & Valganciclovir *In heat bath at boiling

  8. pH Study for maximum flouresence of Ganciclovir & Valganciclovir pH: 1-5 Concentration : 10 µg/ml S/N=11.4 (G) 7.4 (V) at pH 1, <1 after pH 2.5

  9. pH Study for maximum flouresence of Ganciclovir & Valganciclovir pH: 0.2-1 Concentration : 10 µg/ml S/N=7.5

  10. Timeline • Complete calibration curves for ganciclovir & valganciclovir • Complete drug release study for films with ganciclovir & valganciclovir • Characterize films

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