CHE 606

1. CHE 606

2. The chemistry of molecular assemblies. The chemistry of the intermolecular bond. Non molecular chemistry. The chemistry of the non covalent bond. Chemistry beyond the molecule.

3. The impact of supramolecular chemistry as judged by publications from active research programs. Recent articles published this month in the Journal of the American Chemical Society

4. Course Mechanics: role of the instructor of record sage on the stage guide on the side

5. Course Mechanics: Web Site: http://www.ic.sunysb.edu/Class/che606/ Textbook: Supramolecular Chemistry, Steed and Atwood, Wiley, 2000. = lecture Class Meeting Times: Tues 2:20-3:20Wed 5:15-7:00 = workshop

6. d d d d d d H H H H d H H F. W. Fowler - various aspects of supramolecular chemistry F. Raineri – theoretical aspects of the hydrophobic effect J. Lauher – crystal engineering and the CSD. B. Hsiao – supramolecular aspects of block copolymers. lectures D. Drueckhammer – the design of sensors. S. Wong – supramolecular aspects of SWNT derivatives A. Mayr – electronic materials

7. Tools for searching the literature. workshops The Cambridge Structural Database Computational Chemistry - Molecular Modeling and Quantum Mechanical calculations

8. Analysis of recent literature papers with respect to supramolecular chemistry workshops Each student should select the following: 1. two molecules 2. two topics

9. lecture - guests will give lectures on areas and the tools of supramolecular chemistry workshop - students will apply the ideas developed in the lectures to the analysis of recent literature reports

10. Supramolecular Chemistry C H O H 2 C H O H O C H O H + H O O C + 2 2 C H O H O C H O H C H O light molecular chemistry supramolecular chemistry

11. Supramolecular Chemistry Synthetic Chemistry CHE 606

12. Synthetic Chemistry available compounds those thingswe want unique to the discipline chemistry

13. Synthetic Chemistry available compounds Dictyodendrin B J. AM. CHEM. SOC. 2005, 127, 11620-11621

14. Synthetic Chemistry available compounds electronic paper pentacene

15. Synthetic Chemistry available compounds inflammation, pain

16. Synthetic Chemistry available compounds CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2 Nature,2000,405, 97-101

17. Synthetic Chemistry molecular supramolecular available compounds those thingswe want synthesis synthesis

18. Synthetic Chemistry an ensemble of molecules to form the letter H available compounds molecularsynthesis supramolecularsynthesis

19. The early days of molecular synthesis N C H H 3 O O H N q u i n i n e malaria

20. The early days of molecular synthesis N H N C H H 3 O 2 O H N C H 3 q u i n i n e C H N 1 0 1 3 THE TOTAL SYNTHESIS OF QUININER. B. Woodward, W. E. Doering; J. Am. Chem. Soc.;1944; 66(5); 849-849. Stork, G.; et.al. J. Amer. Chem. Soc., 2001, 123, 3239 W. Perkin 1857

21. The early days of supramolecular synthesis Now!

22. The preparation of designed supramolecular structures is significant challenge to modern synthetic chemistry