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Special Populations: Geriatrics

Lecture #30. Special Populations: Geriatrics. % over 60 in the world. Body Composition with Age. BMI with Age. Body Changes. Heart Rate with Age. Blood Pressure. systolic (males). systolic (females). diastolic (males). diastolic (females). Physiological Parameters with Age.

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Special Populations: Geriatrics

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  1. Lecture #30 Special Populations: Geriatrics

  2. % over 60 in the world

  3. Body Composition with Age

  4. BMI with Age

  5. Body Changes

  6. Heart Rate with Age

  7. Blood Pressure systolic (males) systolic (females) diastolic (males) diastolic (females)

  8. Physiological Parameters with Age

  9. Disease: Young vs. Old male female

  10. Disease: Young vs. Old male female

  11. Drug Use: Young vs. Old 1 drug 2 drugs 3 drugs 4 drugs >5 drugs

  12. PK Parameters with Age

  13. PK with Age

  14. PK: Young vs. Old * red squares, black squares and circles are from different studies with gender and liver disease.

  15. PK: Young vs. Old

  16. PD with Age Adjustment of Dose with Age

  17. PD with Age

  18. PD with Age

  19. PDwith Age

  20. Odds Ratio

  21. ADR with Age

  22. A: GI Tract • Increased pH • Decreased GI Blood Flow • Gastric emptying/Motility unchanged

  23. A: GI Tract Problems

  24. D: Protein Binding • Decreased Albumin (Disease) • hydrophobic drugs • Increased a1 acid glycoprotein (Disease) • basic drugs

  25. M: CYPs

  26. M: CYP3A

  27. M: CYP3A

  28. E: Renal

  29. E: Renal

  30. E: Renal

  31. E: Renal

  32. E: Renal

  33. E: Renal

  34. E: Renal

  35. E: Renal • Decreased GFR • Decreased Blood Flow • Decreased Renal Mass • Clinical Consequences?

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