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Gluconeogenesis

Gluconeogenesis. Glucogenic. amino acids. Glycerols (from. Lactate,. triglycerides). pyruvate. Propionate. Krebs cycle. (ruminants). intermediates. Gluconeogenesis. Glucose. Roles of Gluconeogenesis. Provides glucose for the brain Recycles lactate after exercise

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Gluconeogenesis

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  1. Gluconeogenesis

  2. Glucogenic amino acids Glycerols (from Lactate, triglycerides) pyruvate Propionate Krebs cycle (ruminants) intermediates Gluconeogenesis Glucose

  3. Roles of Gluconeogenesis • Provides glucose for the brain • Recycles lactate after exercise • Lactose synthesis in ruminants • Carbohydrate polymers in plants and bacteria • From CO2, acetate, fats, etc…

  4. Review of Glycolysis

  5. Review of Glycolysis

  6. Bypasses of “Irreversible” Glycolysis Steps

  7. Bypasses of “Irreversible” Glycolysis Steps

  8. Bypasses of “Irreversible” Glycolysis Steps

  9. Cori Cycle: Lactate Salvage

  10. Glucose-Alanine Cycle

  11. Gluconeogenesis from Stored Fats • In plants

  12. Gluconeogenesis from Stored Fats • In animals

  13. Gluconeogenesis from Propionate • In ruminants

  14. Fate of Pyruvate: Regulation

  15. Gluconeogenesis and Glycolysis • Reciprocal regulation

  16. Reciprocal Regulation of PFK-1 and FBPase-1 • Both enzymes allosterically regulated by Fru-2,6-bisP

  17. Regulation by Fru-2,6-bisP

  18. Regulation by Fru-2,6-bisP

  19. Fru-2,6-bisP as Regulator

  20. What Regulates [Fru-2,6-bisP]? • Indirectly regulated by the hormone glucagon

  21. PFK-2 and FBPase-1: Same Protein!

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