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A Study by Amarjit Mishra – Metabolic Adaptations in Th2-High Asthma

Amarjit Mishra also discusses the role of the mitochondrial Irg1/itaconate axis in controlling Th2 inflammation as a significant metabolic adaptation. Prior research has established a redox-dependent and related relationship between cross-presentation and allergen absorption by antigen-presenting dendritic cells.<br>

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A Study by Amarjit Mishra – Metabolic Adaptations in Th2-High Asthma

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  1. A STUDY BY AMARJIT MISHRA – METABOLIC ADAPTATIONS IN TH2-HIGH ASTHMA we present an excerpt of a review by Dr. Amarjit Mishra of Auburn University who has been working to improve understanding of the metabolic adaptation and activation of lung immune cells in the development and regulation of airway inflammation, with a focus on immunometabolic pathways in causing asthma heterogeneity.

  2. Dr. Amarjit Mishra and his team are striving to create promising new therapy strategies by increasing their understanding of how immunometabolic pathways regulate airway inflammation and the aetiology of asthma.

  3. the IL-5, IL-13, and IL-4 cytokine production that results from the Th2-mediated lung adaptive immune response is accompanied by a phenotype of eosinophilic inflammation. Pyruvate Kinase M2 expression is one of the significant metabolic modifications emphasised by Amarjit Mishra.

  4. The allergic stimulus-induced Th2 inflammation is initiated by antigen-presenting dendritic cells, which depend on immature mitochondrial oxidative phosphorylation and are regulated by AMPK signalling.

  5. Amarjit Mishra and his team’s results suggest that the dendritic cells migration to draining LN is unaffected by antigen absorption and priming, which are affected by mitochondrial dysfunction. As per the views of the experts, there is a need for further studies on the Irg1/itaconateaxis to explore the immunomodulatory role in dendritic cells effector function and Th2 inflammatory pathways driving asthma pathogenesis. Source:-https://denhet.com/a-study-by-amarjit-mishra-metabolic-adaptations/

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