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Study by Amarjit Mishra – Metabolic Adaptations and Type-2 Low Asthma

Dr.Amarjit Mishra has contributed to the review of the entire system of asthma pathogenesis by performing an extensive literature survey of the prior research as well as carrying out tests utilizing cutting-edge methods to further our understanding of the subject.u00a0<br>

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Study by Amarjit Mishra – Metabolic Adaptations and Type-2 Low Asthma

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  1. Study by Amarjit Mishra – Metabolic Adaptations and Type-2 Low Asthma As a result, Dr. Amarjit Mishra Auburn University was one of the forerunners in discovering this connection and has been working on studies to further substantiate the relationships between the various metabolic adaptations and type-2 mild asthma.

  2. The importance of CD4+ T cell subsets such as Th1, Th2, and Th17 cells in the pathogenesis of autoimmune, allergy, and chronic inflammatory disorders is well-known. The metabolic profile and signatures for each T cell subset are primarily established during antigen presentation and differentiation of naive CD4+ T cells in secondary lymphoid organs, despite the fact that activated effector T cells undergo rapid metabolic switch to support increased energy demand and anabolic functions.

  3. In order to reverse severe asthma’s unresponsive steroid profile, Dr. Mishra noted that FAO inhibition presents an intriguing target for treatment. Dr. Amarjit Mishra who was an Ex-Assistant Professor of Auburn University has also established the diverse roles of mTORCsupramolecules in regulating T-cell polarisation through a variety of assays.

  4. It has long been recognized that the severe asthma phenotype is characterised by the presence of Th17 cells that secrete IL-17. The transcription factor mediating this effector function is RORt.

  5. Dr. Amarjit Mishra has also done extensive research on the function of arginine metabolism in the Th17 pathway. PI3-AKT and mTORCsignalling-dependent production of inducible nitric oxide synthase and nitric oxide, whose levels correlate with the severity of asthma and are frequently used as a biomarker to predict response to therapy, Source:-https://yourgoogledoc.com/auburn-university-ex-professor-dr-amarjit-mishra-explained-allergic-asthma-a-research-perspective/

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