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MAKING PUNNETT PREDICTIONS

MAKING PUNNETT PREDICTIONS. http://www.exploratorium.edu/exhibits/mutant_flies/mutant_flies.html. IF GENE is AUTOSOMAL and RECESSIVE TO WILD TYPE (+) MALES:FEMALES 1:1. m m + +. +m +m +m +m. F 1 All = +m (show wildtype phenotype). + m + m. F 2

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MAKING PUNNETT PREDICTIONS

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  1. MAKING PUNNETT PREDICTIONS http://www.exploratorium.edu/exhibits/mutant_flies/mutant_flies.html

  2. IF GENE is AUTOSOMAL and RECESSIVE TO WILD TYPE (+) MALES:FEMALES 1:1 m m + + +m +m +m +m F1 All = +m (show wildtype phenotype) + m + m F2 ¼ = ++ 75% wildtype ½ = +m ¼ = mm 25% mutant 3:1 ratio ++ +m +m mm http://www.exploratorium.edu/exhibits/mutant_flies/curly-wings.gif

  3. IF GENE is AUTOSOMAL and DOMINANT TO + MALES:FEMALES 1:1 M M + + +M +M +M +M F1 All = +M (mutant) + M + M F2 ¼ = ++ 25% wildtype ½ = +M ¼ = MM 75% mutant 1:3 ratio ++ +M +M MM

  4. F1 Some disorders (YY) is lethal IF GENE is LETHAL (YY) (Can’t cross pure dominant) Males:females 1:1 Y y y y Yy yy Yy yy F1 50% = Yellow 50% = grey F2 Y y Y y F2 ¼ = YY (lethal) ½ = Yy 2/3 yellow ¼ = yy 1/3 grey 2:1 ratio YY Yy Yy yy X

  5. IF GENE is X-LINKED RECESSIVE Different pattern if gene is inherited from mom or dad Mutant mom X wild type dad F1 Xm y X+ Xm F1 X+ y Xm Xm X+Xm X+y XmXm Xmy X+Xm Xmy X+Xm Xmy 25% normal females25% mutant females 25% mutant males25% normal males 50% normal females 50% mutant males When using Virtual fly labChoose ignore sex and see if it changes the ratios

  6. IF GENE is X-LINKED RECESSIVE Different pattern if gene is inherited from mom or dad Wild type mom X mutant dad F1 X+ y X+ Xm F2 Xm y X+ X+ X+Xm X+y X+Xm Xmy X+Xm X+y X+Xm X+y 50% normal females 50% normal males 50% normal females 25% mutant males25% normal males When using Virtual fly labChoose ignore sex and see if it changes the ratios

  7. IF GENE is X-linked dominant MUTANT MOM X WILD TYPE DAD F1 F2 XM y X+ XM X+ y XM XM X+XM X+y XMXM XMy X+XM XMy X+XM XMy 50% mutant females50% mutant males 50% mutant females 25% wild type males25% mutant males When using Virtual fly labChoose ignore sex and see if it changes the ratios

  8. IF GENE is X-linked dominant WILD TYPE MOM X MUTANT DAD F1 X+ y X+ XM F2 XM y X+ X+ X+X+ X+y X+XM XMy X+XM X+y X+XM X+y 50% mutant females 50% normal males 25% wild type females25% mutant females25% wild type males25% mutant males When using Virtual fly labChoose ignore sex and see if it changes the ratios

  9. GENETIC ABBREVIATIONS DOMINANT MUTATIONS: first letter = capitalized. EX: sternopleural bristles= Sp RECESSIVE MUTATIONS = lower case EX: mahogany eyes = mah normal "wild type" version of the gene = same abbreviation as mutant with a "+" superscript For example, Sp+ and mah+. Sometimes, when the meaning is obvious, "+" by itself is used EX: heterozygote genotypes: +/Sp and +/mah. VIRTUAL FLY LAB DOESN’T FOLLOW THIS PROTOCOL:You need to explore and figure out whether it is dominant or recessive.

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