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Supp. Figure 1 : DAS4 does not induce consistent D NA damage within the time of DAS-induced mitotic arrest. 8 h. 4h. 2 h. 1 h. UNTR. FLH-: FL1-phospho - H2A.x. VP16. DAS4. FLH-: FL1-phospho - H2A.x. ***. **. UNTR. DAS4.

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  1. Supp. Figure1: DAS4 does not induceconsistent DNA damage within the time of DAS-induced mitotic arrest 8h 4h 2h 1h UNTR FLH-: FL1-phospho-H2A.x VP16 DAS4 FLH-: FL1-phospho-H2A.x *** ** UNTR DAS4

  2. Supp. Figure2: Effectsof MTdepolymerizingagents on JNK and Bcl-2 phosphorylation VNB VNC V V V DAS4 V DAS4 0h 4h 8h 16h 24h 4h 24h 0h 4h 8h 16h 24h 4h 24h 54KDa p-JNK 46KDa 54KDa JNK 46KDa b-actin 41KDa DAS4 DAS4 VNB VNC V V V V 0h 4h 8h 16h 24h 24h 8h 16h 0h 4h 8h 16h 24h 24h 8h 16h p-Bcl-2 ser70 26KDa 26KDa Bcl-2 24 kDa More exposed cleavedform 24 kDa b-actin 41KDa

  3. Supp. Figure3: Impact ofsmallmolecular Bcl-2 inhibitor on cellcycle/viabilityof U937 cellsin presence/absenceofDAS4 A cells cells B ** ** ***

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