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Physical models for brain physics:

Physical models for brain physics:. Presenter: Spencer Brinker Date: July 28, 2010. Introduction Past Experience and Mission at UIC Central Nervous System Physical Modeling Rapid Prototyping Proposed Model and Experiments Closing Remarks. Past Experience and Current UIC Mission

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Physical models for brain physics:

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  1. Physical models for brain physics: Presenter: Spencer Brinker Date: July 28, 2010 LPPD Group Seminar, July 28, 2010

  2. Introduction • Past Experience and Mission at UIC • Central Nervous System Physical Modeling • Rapid Prototyping • Proposed Model and Experiments • Closing Remarks LPPD Group Seminar, July 28, 2010

  3. Past Experience and Current UIC Mission • B.S Mechanical Engineering 2009 (Southern Illinois University Edwardsville) • Main Objective: Grad School • Past Experience • Electroencephalography (EEG) • Electromyography (EMG) • Arm Prosthetic Design (Control and Actuator) • FEM Analysis (Human Brain Depth Electrodes in Epilepsy) • ConocoPhillips Rigging and Construction Engineer • United States Steel Metallurgical and Maintenance Coordinator • UIC Mission • Working with Tim’s Experiment (present) • Central Nervous System (CNS) Physical Modeling (future) • Magnetic Drug Targeting (future) LPPD Group Seminar, July 28, 2010

  4. CNS Physical Modeling • Recent model (published 2008 IEEE) • In-vitro Measurement of Ventricular Cerebrospinal Fluid Flow using Particle Tracking Velocimetry and Magnetic Resonance Imaging • Matthias Schibli1, Markus Wiesendanger1, Lino Guzzella1, Klaus Hoyer2, Michaela Soellinger3, Vartan Kurtcuoglu1, Peter Boesiger3 • Overview • Pressure Control • Synchronization of MRI and Particle Tracking Velocimetry Pressure Control LPPD Group Seminar, July 28, 2010

  5. Image of Most Recent Physical Model LPPD Group Seminar, July 28, 2010

  6. Introducing Rapid Prototyping Machines to CNS Physical Modeling • RPM Types • Fused Deposition Modeling (FDM) • Stereolithograpgy (SLA) • Polyjet • UIC has FDM (machine broken) FDM 2000 and 3000 LPPD Group Seminar, July 28, 2010

  7. Polyjet FDM SLA LPPD Group Seminar, July 28, 2010

  8. CNS Physical Model with RPM • MRI (DICOM) --- Computational Meshing (STL) --- RPM Prep (SML) • Material • Polyjet has a elastomeric material available • Model Layers and Components • Pulsating Bladder Layer • Inner CSF Tract (Lateral to Forth Ventricles) Layer • Subarachnoid Space (outer shell) Layer • Gray and White Matter Layer • Bladder Inlet • Spinal Canal Passage • Spinal Canal will mimic Tim’s Physical Model LPPD Group Seminar, July 28, 2010

  9. Proposed CNS Physical Model Uses • Topics • CSF Fluid Dynamics Analysis • Drug Delivery • Magnetic Drug Targeting • Proposed Experiments • EEG and Magnetoencephalography (MEG) Analysis of CSF Fluid Dynamics using Ferrofluid Injection. • Apply this model to Tim’s radioactive fluid experiment with Spect Analysis (Single photon emission computed tomography) in the CSF tract. • EEG and MEG Topography Mapping analysis with Ferrofluid Experiment. LPPD Group Seminar, July 28, 2010

  10. Closing Remarks • RPM is only as good as the MRI resolution and the Meshing software. • I believe RPM will play a large role in the future of medical physical modeling from the recent improvements in resolution and multiple material injection. • Thanks for those who helped me with this project! • Questions? LPPD Group Seminar, July 28, 2010

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