ALL ABOUT OLAPARIB or LYNPARZA

1. ALL ABOUT OLAPARIB Better known by its brand name Lynparza, Olaparib is an ADP-ribose polymerase inhibitor that is prescribed to patients who have been diagnosed with ovarian cancer and HER2 negative metastatic breast cancer having BRCA mutations, advanced cases of prostate cancer and pancreatic cancer. Mention may be made of the fact that Olaparib is the only PARP inhibitor that has been approved for all the above-stated conditions. How is it taken? Olaparib Dosage & Usage It comes in pill form and needs to be swallowed whole with water. The typical dose is 300mg which means that the patient would have to consume two 150mg Lynparza tablets every day. The tablets must not be crushed, chewed or dissolved in water. You are also to refrain from dividing the dosage. If the patient develops toxicities that cannot be managed, the doctor will reduce the dosage. The treatment must be continued till the body shows response or until life-threatening side effects are seen. Continuous treatment that lasts up to 2 years can manage the condition quite well. Precautionary Measures 1.The patient is supposed to take the tablets with a gap of 12 hours in between. You can take it with or without food. 2.You are advised to avoid taking more than 4 tablets in a day.

2. 3.Without informing the doctor, don’t stop treatment even if the condition is getting better. 4.Grapefruit and grapefruit juice are not supposed to be consumed by the patient. 5.Apart from that, refrain from taking Seville oranges or drinking marmalades as they can cause the levels of Olaparib to rise in the body. 6.In case if the patient misses a dosage, they are not to make up for it altogether. Continue with your original dose and consult a doctor. 7.Alcoholic beverages are to be cut down to a minimum. 8.Avoid getting pregnant while you are undergoing therapy. Use contraceptives or protection for at least 6 months after the treatment is over. 9.If you are a male patient, refrain from donating sperm for at least 3 months after the treatment. 10.Lactating women should avoid breastfeeding for at least 1 month after receiving the last dosage because the ingredients can pass through breastmilk and cause harm to the baby. 11.Talk to your healthcare professional about all the medications that you are taking at present, including vitamin supplements and herbal remedies as there are chances of the ingredients of Olaparib interacting with these and causing toxicity. Olaparib Side Effects A decrease in blood cell count Bone marrow problems like MDS and AML Frequent infections Fever Bloody urine Shortness of breath Unusual bruising and bleeding • • • • • • • There is a serious condition that can occur in some cases- Pneumonitis. Therefore, if you experience any of the symptoms like fever accompanied by coughing and wheezing, get a chest X-ray. This lung disease is quite severe and can be fatal. Your doctor can stop treatment for the time being if you develop this condition. If you have a history of lung or kidney problems, it is essential that you mention about them to your doctor. Due to the low blood count, the body will be exposed to a lot of infections. Refrain from going to crowded places while you’re taking Olaparib. Final Words You can buy Lynparza 50 mg tablets at the local pharmacy at wholesale market prices. If you are going with an online alternative, check if it is legitimate at first. Olaparib cost in India varies for different pharmacies. The price of 112

3. Lynparza 50 mg tablets is 68,000 INR at present. If you want to get discount on Lynparza price, it is better to buy in bulk. Source: http://ikrispharma.over-blog.com/all-about-olaparib-lynparza.html