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INTRODUCTION

CREDIT SEMINAR PHARMACOLOGY of SEABUCKTHORN ( Hippophae rhamnoides ) PRESENTED BY DR. MILINDMITRA K. LONARE (V-2002-30-13) DEPARTMENT OF PHARMACOLOGY & TOXICOLOGY COVAS, CSKHPKV, PALAMPUR-176062 (INDIA) DATE:29-01-2003. INTRODUCTION. SEABUCKTHORN.

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INTRODUCTION

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  1. CREDIT SEMINARPHARMACOLOGY of SEABUCKTHORN(Hippophae rhamnoides)PRESENTED BYDR. MILINDMITRA K. LONARE(V-2002-30-13)DEPARTMENT OF PHARMACOLOGY & TOXICOLOGYCOVAS, CSKHPKV, PALAMPUR-176062 (INDIA) DATE:29-01-2003

  2. INTRODUCTION

  3. SEABUCKTHORN

  4. ♪ Grows naturally in cold countries on river sides, hill top & sun facing mountains ♪ India- found in dry temporate Himalayas ♪ Himachal pradesh-found in Chamba, Kinnaur, Kullu& Lahaul-Spiti ♪ It is quality fuel wood and fodder ♪ Potential health food

  5. Historical Background ♪ First report - China (8th century), In Yue Wang You Zhen medicinal classic ♪ Second report – Tibetan & Mongolia (18th century), in Sibu Yidian (Tibetan classic) ♪ India – used locally since time immemorial ♪ officially listed by Chinese Pharmacopoeias by ministry of public health (1977)

  6. Composition & Functions • Fruit juice: 60-80 %, 190 kinds of bioactive substances 1. Organic acids (malic/oxalic/unidentified acids) - Terminating toxicity - Protection from teratogenesis & X-ray damage - Prevention from side-effects of O2 therapy 2. Betaines (methylation of glycine) - prevents & cures arteriosclerosis - anti-inflammatory

  7. 3.Triterpene (ursolic acid) - adrenocorticotropic mimetic - controls action of Na+ & Cl- - anti-inflammatory activity 4. Flavonoids (flavonol, catechin, lukocyanidin & flavone) - prevents vit-C oxidation - lowers cholesterol levels - anti-microbial & anti-inflammatory - anti-allergic & anti-tumorogenic

  8. 5. 5–HT (5 - hydroxytryptamine) - regulates B.P. and temperature - influences sleep, intestinal motility, hormonal level & emotions - promote coagulation 6. β- amyrinoleylalcohol acid - dilates cardiac & cerebral vessels - facilitates blood circulation 7. Coumarins - strengthen capillary function - anti-tumorogenic, anti-numbness and anti-pyretic

  9. 8. Triterpene (ursolic acid) - adrenocorticotropic mimetic - controls action of Na+ & Cl- - anti-inflammatory activity 9. Amino acids & Minerals 10. Flavoxanthin, cryptoxanthin and violaxanthin

  10. 11. Progestin 12. Vitamins - β-carotenes (250 mg/100gm) - Vit.-C, K, E 13. Steroides(ergosterols, stigma sterols, lanosterols & amyrins ) 14. Tannic acid 15. Fatty acids

  11. Seed oil: 8-18 %, 106 bioactive substances 1. 22 kinds of fatty acids (saturated-13.7% & unsaturated-86.3%) - linolenic acid (omega-3 & 6) - oleic acid- control cholesterol level - anti-diabetics, obesity & cancer - essential for fat soluble vitamins

  12. 2. 6 knds of fat soluble vitamins - vit.A; carotene-249mg/100g - vit.E-203mg/100g - vit.K-150mg/100g 3. 36 kinds of flavonoids and phenols - anti-oxidation, anti-radiation - enhancement of cachettin & quassium functions

  13. 4. 42 kinds of phospholipids - strengthen the membrane mitochondria - participation in electron migration - oxidative phosphorylation & cellular metabolism • Fruit residue: - 20 % of total wt. - rich in proteins, amino acids, carotene, vitamin C (426-503 mg/100g), microelements

  14. Nutritional value

  15. Seabuckthorn berries & leaves

  16. Effect of fodder supplementation

  17. PHARMACOLOGY of SEABUCKTHORN

  18. Healing potential • Plays role in ulcer, wound and skin burn • Causes regeneration of tissues • Granulation of tissue formation (8 days) Antimicrobial activity • Purified tannin from SBT having play role • Having broad spectrum activity

  19. Cytoproctective & Anti-oxidant activity • CEH having capacity of anti-oxidant • Increases elimination of free radical • Decreases glutathione peroxidase and glutathione level • Decreases cytotoxicity and apoptosis • Restore the phagocytic activity

  20. Role in age related memory disorder • Prevent neurological, endocrine & metabolic effects • Alter the level of amines • Prevent Ach level loss

  21. Nerophysiological adaptation(Cold stress) • Prevent cardiovascular response to cold stress • Reduces epinephrine and norepinephrine level • Reduces plasma cortisol level

  22. Cardiovascular diseases • Omega-3 fatty acid decreases risk • Decreases total and LDL cholesterol, triglyceroides & lipoproteins • Alter the platelet aggregation factor • Strengthen the myocardial contraction

  23. Immune mechanism • Prevent membrane phosphorylatio • Prod. of Eicosanoids & cytokines • Increases serum lysosomes & Alexin level • Increases natural killer cell level • Enhances T-lymphocyte proliferation & IL-2 secretion

  24. Anti-inflammatory activity • Carotene, Vit. E & PUFA play role • Counter checks senilism by controlling proteometabolism and metabolism of nucleic acid • Prevent damage due to radiation • Facilitate the exudation & hematopedesis • Enhances cellular infiltration & metabolism

  25. Anti-tumorigenesis • Direct act through general immunity • Inhibits the growth of gastric carcinoma & lymphatic leukemia • Blocks the synthesis of N-nitrosomolane • Increases superoxide dismutase activity

  26. Other activities • Protects from pain in stomach, liver, chest & lumbar region • Prevents hepatic damage - CCl4, alcohol & paracetamol • Used in gynecological ailments • Used for treatment of cough & cleaning lung • Used as cosmetic

  27. Toxicity • Acute & chronic toxicity • Toxic dose: • Oil: 20-30 % in diet • Effects- other than vegetative & CNS • Fruit: 40 % in diet • Increases bilirubin • Decreases TLC • Fruits: 100 % feeding • Fatal to all animals

  28. CONCLUSION • Store-house of many bioactive substances • Possesses diverse pharmacological activities • Useful for prevention of diseases • Has great nutritional value • As a alternative remedy for treatment of diseases

  29. THANKS

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