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Three Key Neurotransmitter Systems of Antidepressants

Three Key Neurotransmitter Systems of Antidepressants. Norepinephrine Dopamine Serotonine. Stahl S M, Essential Psychopharmacology (2000). 5-19. NOREPINEPHRINE RECEPTORS. presynaptic alpha 2 autoreceptor. postsynaptic alpha 2 receptor. alpha 1 receptor. postsynaptic beta 1 receptor.

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Three Key Neurotransmitter Systems of Antidepressants

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  1. Three Key Neurotransmitter Systemsof Antidepressants • Norepinephrine • Dopamine • Serotonine

  2. Stahl S M, Essential Psychopharmacology (2000) 5-19 NOREPINEPHRINE RECEPTORS presynaptic alpha 2 autoreceptor postsynaptic alpha 2 receptor alpha 1 receptor postsynaptic beta 1 receptor

  3. DOPAMINE RECEPTORS Stahl S M, Essential Psychopharmacology (2000) 5--33 presynaptic autorecptor dopamine transporter D2 D3 D4 D1 D5

  4. SEROTONIN RECEPTORS Stahl S M, Essential Psychopharmacology (2000) 5--36 5HT1D autoreceptor alpha 2 hetero receptor serotonin transporter 5HT3 5HT4 5HT2C 5HTX 5HT2A 5HTY 5HTZ 5HT1A

  5. SSRI Pharmacological Profile Powerful 5HT disinhibition in key passways • from midbrain raphe to prefrontal cortex • from midbrain raphe to basal ganglia • from midbrain raphe to limbic cortex and hippocampus • from midbrain raphe to hypothalamus • from midbrain raphe to spinal cord

  6. Stahl S M, Essential Psychopharmacology (2000) 5--51 Serotonin Pathways Raphe Nucleus

  7. Frontal Cortex Mood Stahl S M, Essential Psychopharmacology (2000) 5--52

  8. Akathisia/ Agitation Basal Ganglia OCD Stahl S M, Essential Psychopharmacology (2000) 5--53

  9. Limbic Anxiety Stahl S M, Essential Psychopharmacology (2000) 5--54

  10. Hypothalamus Appetite/bulimia Stahl S M, Essential Psychopharmacology (2000) 5--55

  11. Sleep Centers Insomnia Stahl S M, Essential Psychopharmacology (2000) 5--56

  12. SEROTONIN RECEPTORS Stahl S M, Essential Psychopharmacology (2000) 5--36 5HT1D autoreceptor alpha 2 hetero receptor serotonin transporter 5HT3 5HT4 5HT2C 5HTX 5HT2A 5HTY 5HTZ 5HT1A

  13. Stahl S M, Essential Psychopharmacology (2000) 5-19 NOREPINEPHRINE RECEPTORS presynaptic alpha 2 autoreceptor postsynaptic alpha 2 receptor alpha 1 receptor postsynaptic beta 1 receptor

  14. 5HT brake 5HT accelerator Stahl S M, Essential Psychopharmacology (2000) 5--48 serotonin neuron postsynaptic alpha 2 hetero receptor presynaptic alpha 2 autoreceptor alpha 1 receptor presynaptic alpha 2 autoreceptor norepinephrine neuron

  15. 5HT1A anti- depressant anxiolytic sleep restoring anxiolytic 5HT2A no sexual dysfunction weight gain 5HT2C anxiolytic no nausea 5HT3 no GI problems Stahl S M, Essential Psychopharmacology (2000) 7-11

  16. H1 SRI TCA M1 NRI Stahl S M, Essential Psychopharmacology (2000) 6-27

  17. 5-HT1A • Antidepressant • Anxiolytic • Lowering temperature

  18. depression lifts SRI inserted depression lifts Stahl S M, Essential Psychopharmacology (2000) NRI inserted 6-28 6-29

  19. weight gain drowsiness H1 inserted blurred vision constipation LAXATIVE drowsiness dry mouth M1 inserted Stahl S M, Essential Psychopharmacology (2000) 6-30 6-31

  20. decreased blood pressure dizziness inserted Stahl S M, Essential Psychopharmacology (2000) 6-32

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