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RECRUITMENT TALK

RECRUITMENT TALK. Remember There are few positions and many candidates 200-500 candidates for any tenure track faculty position 10 qualified people for each position I receive 30-50 unsolicited requests per month Step 1: Getting the Interview CV and personal statement

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RECRUITMENT TALK

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  1. RECRUITMENT TALK Remember There are few positions and many candidates 200-500 candidates for any tenure track faculty position 10 qualified people for each position I receive 30-50 unsolicited requests per month Step 1: Getting the Interview CV and personal statement Review standard University CV formats I do not care what you think your skills are I want to know what you have produced I want to know what your training is I will respond better to what I am used to seeing

  2. RECRUITMENT TALK • What am I looking for in a trainee candidate • What am I looking for in a faculty candidate

  3. RECRUITMENT TALK • You only get one chance to make a first impression • Arrive early • Dress Professionally • Males Tie and Jacket • Females Consider a suit • At least a dress or skirt. • Live with your clothes. Do not fidget • I am looking for a professional colleague • Slides must be clear, single format

  4. RECRUITMENT TALK • What am I looking for in a trainee candidate • Career goals • What do you want to do in 5 years • How will you get there: • What are your strengths and weaknesses • Are you driven to succeed • Talk • Organization • Thought process • Much more important than the data • Handling questions more important than the talk • NEVER EVER INTERRUPT • I am making a commitment to your career • Will you be successful • Are you teachable • Do you want to learn or do you already know it all

  5. RECRUITMENT TALK • What am I looking for in a Faculty Candidate • Someone I trust • Represent me in meetings • Not cause problems in and for the department • A team player and collaborator: Team sports • There is no “I” in a talk • Someone I want to work with, go to dinner with, go to meetings with • Someone who will make me better or my life easier • Will they teach classes well • Will they get grants • Are they going to be a good teacher • Are they intellectually curious; Will they listen to my questions. Will they review my grant and help me • Have they asked their supervisor about the project and what they can take with them

  6. RECRUITMENT TALK • There are many candidates. • Recruitment is occasional. • For students, we are looking at being • together for 4-6 years, PDFs 3-4 years, faculty a lifetime. • Divorce (termination) is painful • Estimated cost of a “wrong” faculty rectruitment: 750K • There are many ways to make a mistake, few to make a good first impression • Better to recruit no one than the wrong one

  7. RECRUITMENT TALK 3 PARTS Scientific Presentation One on one interviews Dinner

  8. RECRUITMENT TALK PREPARATION FOR THE TRIP Its not all about the talk DO YOUR HOMEWORK. Institution If you are going to Duke, know about the basketball team If you are going to UT, know about the football team Texas A and M, know what an Aggie is. People Study your agenda Know who you are meeting. Review online. What is their latest paper. Know their history Many people have websites or lab websites IL2, LAKs and TILs Know who you are going to dinner with

  9. RECRUITMENT TALK TALK Prepare practice and give it to as many people who will listen Have people look at slides Spelling errors, too busy Use SpellCheck PDF presentation is safest approach Do not tell jokes or try to be funny. You can have an amusing slide NO motion slides unless absolutely necessary If possible overlay slides if motion needed

  10. RECRUITMENT TALK THE TALK Expect to be nervous Where to stand Your slides can be crutches. Do not read your slides but they are there if you need them Speak slowly and clearly If you get lost, do not panic. Take a deep breath and start again. Make clear transitions. A few second gap is OK. Tell one or maybe two stories well, not many. Do not assume anyone has read your favorite papers including your own.

  11. RECRUITMENT TALK THE TALK • Every slide should have a message and a reason to be in the talk • Tell a story. The talk should have a beginning middle and end. • Place the topic in context • Big picture • Logic flow: A set of slides showing what you will present: Fade in an out. • Results • Conclusion • Appropriate amount of time • 45 minutes

  12. RECRUITMENT TALK • THE TALK • Are you logical • Are you careful • Acknowledge anyone who did the work on the slide • Introduction • Put the topic in context • Enough background so people understand the question • What is the question • Why is this important

  13. RECRUITMENT TALK • The four slide cassette Introduction slide Set the question Present a model describing the question A picture is worth a thousand words! Method slide What was done and why Explain the approach and why Data slide Make a new slide for the talk with key points only NOT from your paper Controls are critical Are you careful. Conclusion/transition slide What does the data show you Go back to your model Present a revised model slide What is the next question Set the next cassette

  14. RECRUITMENT TALK • THE END • What have you learned • What are the next questions • One and maybe two slides • What would the title of your grant application be • What is the model • What are the aims

  15. RECRUITMENT TALK • THE DREADED DINNER • Do not drink AT ALL • It is too easy to sip too many times. • If they order you a drink or a glass of wine pick it up put it to your lips occasionally and do not drink • Think about what you order • Order a salad • Main course should be easy to eat • Skip desert • Only order coffee after others • DO NOT order spaghetti. • Do not discuss politics or religion unless asked and then say little and try to change the topic • Nobody cares about how they do things at home • You must participate • People like to talk about themselves • Where are they from. How did they get to the institution. Why did they come • Try to sit next to someone you know or the recruit leader • The Dinner is not a time to ask contentious questions

  16. THE OFFER • Review carefully • Ask questions but not too many • No one wants to work with someone who is a pain • Your best chance to negotiate is up front • No one wants to work with someone who is not excited about the job. Too much negotiation will lose the job • Produce and renegotiate • Produce and move elsewhere

  17. WHAT GOES AROUND COMES AROUND: MULTIPLE GENOMIC AMPLICONS TARGET VESICLE RECYCLING AND BIOENERGETICS Joe Gray William Muller Jim Norman Gordon B. Mills Department of Systems Biology

  18. 15 years of fishing in the genome pool FISHING CAN WORK IF YOU USE THE RIGHT BAIT JOE GRAY LBL AND FRIEND

  19. Early Stage Breast Cancer Resource (2408 tumors Stage 1,2 paraffin n= 971 MIP arrays) Decision tree analysis * * * * * * * * * * Melissa Bondy, Patricia Thompson, Spyros Tsavichidis

  20. GENOMIC ABERRATIONS TARGET ENDOCYTOSIS AND POLARITY PKCi PIK3CA MDS1 EVI1 Mir PVT1 Myc ERBB2 Grb7 Rab11FIP1 RCP Cyclin D1 ZNF217 Rab25

  21. RAB11FIPS AND RAB11 FAMILY MEMBERS ARE OVEREXPRESSED IN CANCER Bittner Oncomine

  22. RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS Rab25 is expressed in ER positive and HER2 positive, low in basal, absent in Claudin low Ju-Seog Lee Fan Zhang

  23. RAB25 AND RCP COOPERATE IN LUMINAL B TUMORS Ju-Seog Lee Fan Zhang

  24. RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin RECYCLING Specific Signaling Complexes DECISION DEGRADATION Jim Norman

  25. RAB25 AND RCP REGULATE MOTILITY AND INVASION THROUGH SPATIALLY RESTRICTED RECYCLING AND LOCALIZED SIGNALING Jim Norman

  26. Rab25 drives extension of invasive pseudopods • Rab25/a5b1 compartment is located near the tip GFP-a5 integrin Cherry-Rab25 N Patrick Caswell/Heather Spence

  27. RAB25 INTERACTS WITH EGFR Roshan Agarwal Kwai Wa Cheng

  28. RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin RECYCLING Specific Signaling Complexes DECISION RAB25 includes a sequence change found in mutant RAS and should be GTP bound Dominant active Rab11 family member Rab25 preferentially binds RCP and integrins in presence of Rab11 DEGRADATION RAB11 GDP RAB25 GTP

  29. RAB25 AND RCP REGULATED VESICLE RECYCLING MEDIATE PLEIOMORPHIC FUNCTIONS Polarity Proliferation Migration Invasiveness Apoptosis Cargoes Integrins Gluts EGFR family Transferrin RECYCLING Specific Signaling Complexes DECISION RAS AKT Raf Mek GSK3 TGFb signaling DEGRADATION MAPK

  30. RAB25 AND RCP EXIST AS A HETEROTETRAMERIC COMPLEX Greg Verdine Stapled peptides Rab25 Rab25 RCP RCP

  31. RAB25 INTERACTION NET: ReMTH, Yeast two hybrid, ip Mass Spec, Lumiere, Literature, STRING GLUT1 Actin capping protein Integrina5 b1 RCP EGFR AKT TGFbR1 Igor Jurisica, Roshan Agarwal, Zhiyong Ding, Kwai Wa Cheng, Jim Norman

  32. RAB25 TRANSCRIPTOME IMPLICATES RAB25 IN BIOENERGETICS 53-gene signature Roshan Agarwal Kwai Wa Cheng

  33. GLYCOGEN IS A POTENTIAL ENERGY SOURCE AKT GSK3 Rab 25 GPI

  34. ATP and GLYCOGEN ARE INCREASED BY RAB25 Kwai Wa Cheng

  35. GLYCOGEN STORES CONTRIBUTE TO THE ABILITY OF RAB25 TO MAINTAIN ATP LEVELS Rab 25 Roshan Agarwal Kwai Wa Cheng

  36. Mechanisms of action of Rab25

  37. COLLABORATORS MILLS LAB Joe Gray LBL Rab25 Kwai Wa Cheng Bill Muller McGill Canada Roshan Agarwal Sofie Claerhout Jim Norman Beatson Scotland Yiling Lu Qinghua Yu Igor Jurisica University of Toronto Shuangxing Yu Shreya Mitra ReMTH Zhiyong Ding Robert Bast MD Anderson Bioenergetics Ju Seog Lee MD Anderson Jae Ho Cheong Jiyong Liang RPPA/PI3K/Patient samples outcomes Yiling Lu Bryan Hennessy Ana Gonzalez Mark Carey Fan Zhang

  38. MDACCSan Francisco Joe Gray Wenlin Kuo Ju-Seog Lee Prahlad RamBoston Joan Brugge Levi Garraway Gabor Balazsi John Albeck Yoko Irie Shiaw-Yih “Phoebus” Lin St. Louis Chuck Perou Georg Halder Vanderbilt Carlos Arteaga Gabriel Hortobagyi UBC Sam Aparicio David Huntsman Funda Meric-Bernstam Baylor Zhou “Sunny” Songyang Robert Bast Cheryl Walker Powel Brown Adrian Lee Jenny Chang Steve Kornblau Holland Rene Bernards Melissa Bondy John Heymach Norway Anne-Lise Boerresen-Dale Michael Andreeff Therese Sorlie Eric Jonasch Spain Jose Baselga Ana Lluch Tissue Bank Ayesegul Sahin Toronto Patricia Shaw Heather Begley Karen Lu Ignacio Wistuba San Francisco Karen Smith McCune Rosemarie Schmandt BioinformaticsToronto Igor Jurisica Kevin Coombes John Weinstein San Francisco Paul Spellman, William Gibb Jonas Almeida Keith Baggerly Sach Murkherjee Mandri Obeyesekere GSK/Semafore/Abbott/Exelixis/Keryx COLLABORATORS

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