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On the origin of the genetic code

Explore the groundbreaking work of Eörs Szathmáry at Collegium Budapest and Eötvös University on the origins and structure of the genetic code. Delve into variants, amino acid biosynthesis, coevolution, precursor-product pairs, and constraints on codon reshuffling. Discover the transition from RNA to protein evolution, tRNA evolution, and protein folding dynamics. Examine tryptophan-binding aptamers, code evolution mechanisms, and intriguing implications for amino acid synthesis. This comprehensive overview sheds light on the fascinating complexity of genetic code evolution.

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On the origin of the genetic code

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  1. On the origin of the genetic code Eörs Szathmáry Collegium Budapest Eötvös University

  2. The structure of the genetic code

  3. Variants of the common code

  4. Amino acid biosynthesis in E. coli

  5. Coevolution chart • Precursor-product pairs in biosynthesis • Dashed boxes are hypothetical intermediate stages • Italicised codons do not match coevolution predictions

  6. Constraints on codon reshuffling for statistical investigations

  7. 3 ways of code evolution

  8. Forces may have changed in strength

  9. Cofactor use by aptamers

  10. From RNA to protein • Gradual lose of scaffold • Amino acids to peptides to proteins • Not very well worked out

  11. Piecewise evolution of tRNA

  12. Proteins from pieces

  13. Superfolds

  14. Some more proteins

  15. Ribosomal proteins cannot fold by themselves

  16. Tryptophan-binding aptamers

  17. The smallest typtophan binder • The anticodon is CCA • 13 fully conserved nucleotides (26 bits of information) • Selective among hydrophobic changes

  18. An interesting idea? • First two bases of a codon implied in synthesis of amino acids originating from the reductive citric acid cycle

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